6-Chloro-2-naphthoic acid

Base Information

• Chemical Name: 6-Chloro-2-naphthoic acid
• CAS No.: 5042-97-7
• Molecular Formula: C11H7ClO2
• Molecular Weight: 206.628
• Hs Code.: 2916399090
• Mol file: 5042-97-7.mol

Synonyms:2-Naphthalenecarboxylic acid,6-chloro;6-Chlor-[2]naphthoesaeure;6-chloro-2-naphthalenecarboxylic acid;6-chloro-[2]naphthoic acid;

Chemical Property of 6-Chloro-2-naphthoic acid

Chemical Property:

• Melting Point: 285-286 °C
• Boiling Point: 366.6±17.0 °C(Predicted)
• PKA: 4.06±0.30(Predicted)
• PSA: 37.30000
• Density: 1.395±0.06 g/cm3(Predicted)
• LogP: 3.19140
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

6-chloronaphthalene-2-carboxylicacid 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Chloro-2-naphthoic acid

There total 1 articles about 6-Chloro-2-naphthoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon monoxide (201230-82-2) + 2,6-dichloronaphthalene (2065-70-5) → 2,6-Naphthalenedicarboxylic acid (1141-38-4) + 6-chloronaphthalene-2-carboxylic acid (5042-97-7)

Guidance literature:

With dicobalt octacarbonyl; potassium carbonate; methyloxirane; In methanol; at 60 ℃; for 7h; under 760 Torr; Title compound not separated from byproducts;

DOI:10.1007/s11167-005-0619-y

Reference yield: 95.0%

(1S,2R,4S)-N2-(tert-butoxycarbonyl)-4-(N,N-dimethylcarbamoyl)-1,2-cyclohexanediamine (365998-36-3) + 6-chloronaphthalene-2-carboxylic acid (5042-97-7) → tert-butyl {(1R,2S,5S)-2-[(6-chloro-2-naphthoyl)amino]-5-[(dimethylamino)carbonyl]cyclohexyl}carbamate

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 22h;

DOI:10.1016/j.bmc.2009.10.024

Reference yield: 51.28%

6-chloronaphthalene-2-carboxylic acid (5042-97-7) + trans-N-(4-aminocyclohexyl)-2-(4-chloro-3-fluorophenoxy)acetamide 2,2,2-trifluoroacetate → trans-6-chloro-N-(4-(2-(4-chloro-3-fluorophenoxy)acetamido)cyclohexyl)-2-naphthamide

Guidance literature:

6-chloronaphthalene-2-carboxylic acid; trans-N-(4-aminocyclohexyl)-2-(4-chloro-3-fluorophenoxy)acetamide 2,2,2-trifluoroacetate; With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

carbon monoxide

2,6-dichloronaphthalene

Downstream raw materials:

6-chloronaphthalen-2-amine

2-(chloromethyl)-6-chloronaphthalene

2-(chloromethyl)-6-methoxynaphthalene

Refernces