1141-38-4

Usage

Uses

Used in Coatings Industry:
2,6-Naphthalenedicarboxylic acid is used as a component in resinous and polymeric coatings that come into contact with food, providing high strength and excellent dyeing properties to the coatings.
Used in Textile Industry:
2,6-Naphthalenedicarboxylic acid is used as a monomer for the manufacture of polyester fibers with high strength and excellent dyeing properties, making it an essential component in the production of textiles.
Used in Electrical Insulation Industry:
2,6-Naphthalenedicarboxylic acid is used as a monomer in the production of F class insulation material, contributing to its high performance and reliability in electrical applications.
Used in Polymer and Resin Industry:
2,6-Naphthalenedicarboxylic acid is an important monomer for the production of high-performance polymers such as PEN (Polyethylene Naphthalate), PBN (Polybutylene Naphthalate), liquid crystal polymer (LCP), and polyurethane resin, which are used in various applications including pharmaceutical and fine chemicals.
Used in Metal-Organic Coordination Polymers (MOCPs) and Metal-Organic Frameworks (MOFs) Industry:
2,6-Naphthalenedicarboxylic acid (H2ndc) is used in the formation of MOCPs for potential applications in fields such as adsorption, separation, and magnetism. It can also be used as a monomer in the synthesis of MOFs, which can further be utilized as drug carriers in the pharmaceutical industry.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C12H8O4/c13-11(14)9-3-1-7-5-10(12(15)16)4-2-8(7)6-9/h1-6H,(H,13,14)(H,15,16)/p-2

Upstream product

• 31656-49-2 naphthalene-2,6-dicarbonitrile 
• 91-20-3 naphthalene 
• 67-63-0 isopropyl alcohol 
• 5859-93-8 naphthalene-2,6-dimethanol 
• 518-05-8 Naphthalene-1,8-dicarboxylic acid 
• 581-42-0 2.6-dimethylnaphthalene 
• 4542-77-2 2,6-bis(bromomethyl)naphthalene 
• 840-65-3 dimethyl 2,6-naphthalenedicarboxylate 
• 222044-40-8 2,6-naphthalenedicarboxylic acid triethylamine 
• 124-38-9 carbon dioxide 
• 13720-06-4 2,6-dibromonaphthalene 
• 91-57-6 2-Methylnaphthalene 
• 5156-83-2 6-methyl-2-acetonaphthone 
• 24157-81-1 2,6-diisopropylnaphthalene 

Downstream Products

• 840-65-3 dimethyl 2,6-naphthalenedicarboxylate 
• 46711-49-3 2,6-naphthalenedicarboxamide 
• 128018-90-6 6-(benzyloxycarbonyl)-2-naphthoic acid 
• 91-20-3 naphthalene 
• 124-38-9 carbon dioxide 
• 749846-69-3 5,5?-((naphthalene-2,6-dicarbonyl)bis(azanediyl))diisophthalic acid 
• 5859-93-8 naphthalene-2,6-dimethanol 
• 745078-25-5 naphthalene-2,6-dicarbodithioic acid dibenzyl ester 
• 5060-65-1 2,6-naphthalenedicarbaldehyde 
• 98331-88-5 2,6-diamino-1,4,5,8-tetranitronaphthalene 

Relevant academic research and scientific papers

Preparation of 2,6-naphthalic acid by liquid phase oxidation of 2,6-diisopropyl naphthalene

An orthogonal experiment was carried out and the effects of bromine, metal ions additives and organic nitrogen compounds on the yield of 2,6-naphthalic acid were discussed. The results shown that influence order for the yield of 2,6-naphthalic acid in the

Discovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP

The Rho family of Ras superfamily small GTPases regulates a broad range of biological processes such as migration, differentiation, cell growth and cell survival. Therefore, the availability of small molecule modulators as tool compounds could greatly enhance research on these proteins and their biological function. To this end, we designed a biochemical, high throughput screening assay with complementary follow-up assays to identify small molecule compounds inhibiting MgcRacGAP, a Rho family GTPase activating protein involved in cytokinesis and transcriptionally upregulated in many cancers. We first performed an in-house screen of 20,480 compounds, and later we tested the assay against 342,046 compounds from the NIH Molecular Libraries Small Molecule Repository. Primary screening hit rates were about 1% with the majority of those affecting the primary readout, an enzyme-coupled GDP detection assay. After orthogonal and counter screens, we identified two hits with high selectivity towards MgcRacGAP, compared with other RhoGAPs, and potencies in the low micromolar range. The most promising hit, termed MINC1, was then examined with cell-based testing where it was observed to induce an increased rate of cytokinetic failure and multinucleation in addition to other cell division defects, suggesting that it may act as an MgcRacGAP inhibitor also in cells.

Cerium-based metal organic frameworks with UiO-66 architecture: Synthesis, properties and redox catalytic activity

A series of nine Ce(IV)-based metal organic frameworks with the UiO-66 structure containing linker molecules of different sizes and functionalities were obtained under mild synthesis conditions and short reaction times. Thermal and chemical stabilities were determined and a Ce-UiO-66-BDC/TEMPO system was successfully employed for the aerobic oxidation of benzyl alcohol.

Preparation method of dimethyl 2, 6-naphthalate

The invention discloses a preparation method of dimethyl 2, 6-naphthalate. Specifically, the preparation method of the dimethyl 2, 6-naphthalate disclosed by the invention comprises the following steps: carrying out esterification reaction on 2, 6-naphthalic acid and methanol under a pressurization condition in the presence of a catalyst, and filtering without further purification to obtain the dimethyl 2, 6-naphthalate, wherein the mass ratio of the methanol to the 2, 6-naphthalic acid is (3: 1)-(25: 1), the reaction temperature ranges from 100 DEG C to 150 DEG C. According to the preparation method disclosed by the invention, the operation is simplified, the yield of the dimethyl 2, 6-naphthalate is improved, and meanwhile, the purity of the dimethyl 2, 6-naphthalate is maintained.

Preparation method of 2,6-naphthalene dicarboxylic acid

The invention relates to a preparation method of 2,6-naphthalene dicarboxylic acid, and solves the problem of high content of 2-acetyl-6-naphthalene dicarboxylic acid in crude 2, 6-naphthalene dicarboxylic acid generated by air oxidation of 2, 6-diisopropylnaphthalene in the prior art. The problem is well solved by adopting the preparation method of 2,6-naphthalene dicarboxylic acid, which comprises the following steps of: (1) adding acetic acid and a compound containing Co, Mn, Br and K into a reaction kettle; (2) controlling the temperature of the reaction kettle to be 160-220 DEG C and the pressure to be 2-3MPa, and adding 2, 6-diisopropylnaphthalene and sufficient gas containing free oxygen into the reaction kettle; and (3) reacting for at least 0.5 hour, and then adding a permanganate alkali metal salt and continuing to react for at least 10 minutes.

Method for preparing aromatic carboxylic acid compound

The invention discloses a method for preparing an aromatic carboxylic acid compound. The method comprises the following steps: 1) heating carbon dioxide and hydrosilane in the presence of a copper catalyst in a reaction medium A; and 2) adding a reaction medium B, aryl halide, a palladium catalyst and a base to the reaction mixture in the step 1), sealing the reaction system, and performing a heating reaction. The method has the advantages that raw materials are simple and easy to obtain, the raw materials are cheap and stable, the catalyst is common, easy to obtain and stable, the reaction conditionsaremild, the aftertreatment is simple, the yield is high, and the like.

Method for preparing high-purity naphthalic acid by taking beta-methylnaphthalene as raw material

The invention discloses a method for preparing high-purity naphthalic acid by taking beta-methylnaphthalene as a raw material. The method comprises the following steps of (1) preparation of an acylation solution, wherein propionyl chloride is added into nitrobenzene and anhydrous aluminium trichloride, and it is controlled that the temperature is below 0 DEG C, so that a mixed solution is mixed into a uniform and transparent solution; (2) an acylation reaction, wherein the acylation solution obtained in step (1) is added into a nitrobenzene solution of 2-methylnaphthalene dropwise, it is controlled that the temperature is below 0 DEG C, and the acylation reaction is carried out; (3) hydrolysis of an acylate, wherein distilled water is added into the product obtained in step (2) for cleaning until the pH value of a mixed solution is 6-7; (4) reduced pressure distillation, wherein the product obtained in step (3) is subjected to reduced pressure distillation, the acylate flows out at 165-180 DEG C, cooling is carried out, and a white solid is obtained; (5) purification of the acylate, wherein the product obtained in step (4) is purified by using a recrystallization method, 2-methyl-6-propiononaphthone is obtained, and vacuum drying is carried out; (6) an oxidation reaction, wherein the product obtained in step (5) is synthesized into 2,6-NDA through an air liquid phase oxidationreaction technology.

Method for preparing high-purity naphthalic acid by taking naphthalene as raw material

The invention discloses a method for preparing high-purity naphthalic acid by taking naphthalene as a raw material. The method comprises the following steps of 1) an alkylation reaction, wherein naphthalene, 1-isopropylnaphthalene and a catalyst are added into a reaction kettle, propylene is introduced for heating for a reaction, and diisopropylnaphthalene is obtained; 2) rectification/crystallization separation, wherein crude 2,6-diisopropylnaphthalene is obtained through rectification, and then high-purity 2,6-diisopropylnaphthalene is obtained through a crystallization method; 3) an oxidation reaction, wherein one or a mixture of a Co-Mn-Br catalyst, glacial acetic acid and propionic acid serves as a solvent, oxygen-containing gas is used for oxidizing diisopropylnaphthalene, and 2,6-naphthalic acid is obtained through liquid-phase synthesis; 4) purification, wherein an object obtained in step 3 is subjected to solid-liquid separation, washing and drying, and 2,6-naphthalic acid solid powder is obtained.

METHOD FOR PRODUCING 2,6-NAPHTHALENE DICARBOXYLIC ACID

An object of the present invention is to provide a method for producing high-purity 2,6-NDA having a small alkali metal content. The present invention relates to a method for producing a high-purity 2,6-naphthalene dicarboxylic acid, comprising a purification step of washing a crude 2,6-naphthalene dicarboxylic acid having a specific surface area of 2 m2/g or more in the presence of an aqueous medium under a temperature condition of 90° C. or more and less than 200° C.

Tandem one-pot CO2 reduction by PMHS and silyloxycarbonylation of aryl/vinyl halides to access carboxylic acids

The present study discloses the synthesis of aryl/vinyl carboxylic acids from Csp2-bound halides (Cl, Br, I) in a carbonylative path by using silyl formate (from CO2 and hydrosilane) as an instant CO-surrogate. Hydrosilane provides hydride for reduction and its oxidation product silanol serves as a coupling partner. Mono-, di-, and tri-carboxylic acids were obtained from the corresponding aryl/vinyl halides.