2-Benzyl-6-chloro-2H-pyridazin-3-one

Base Information

• Chemical Name: 2-Benzyl-6-chloro-2H-pyridazin-3-one
• CAS No.: 50500-58-8
• Molecular Formula: C11H9ClN2O
• Molecular Weight: 220.658
• Mol file: 50500-58-8.mol

Synonyms:2-benzyl-6-chloro-2H-pyridazine-3-one;1-Benzyl-3-chlor-pyridazinon-(6);2-Benzyl-6-chloro-2H-pyridazin-3-one;

Chemical Property of 2-Benzyl-6-chloro-2H-pyridazin-3-one

Chemical Property:

• Melting Point: 98 - 99 °C
• PSA: 34.89000
• LogP: 1.94500

Purity/Quality:

99% ^*data from raw suppliers

2-Benzyl-6-chloro-2H-pyridazin-3-one 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzyl-6-chloro-2H-pyridazin-3-one

There total 1 articles about 2-Benzyl-6-chloro-2H-pyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

6-chloro-2H-pyridazin-3-one (19064-67-6) + benzyl bromide (100-39-0) → 2-benzyl-6-chloropyridazin-3(2H)-one (50500-58-8)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; In acetonitrile; at 90 ℃; for 2h;

DOI:10.1021/ol102703w

Reference yield: 97.0%

m-trifluoromethylphenyl iodide (401-81-0) + 2-benzyl-6-chloropyridazin-3(2H)-one (50500-58-8) → 2-benzyl-6-chloro-4-(3-(trifluoromethyl)phenyl)pyridazin-3(2H)-one (1345839-61-3)

Guidance literature:

2-benzyl-6-chloropyridazin-3(2H)-one; In tetrahydrofuran; at 20 ℃; for 0.00305556h; Inert atmosphere;

m-trifluoromethylphenyl iodide; With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1021/jo201587j

Reference yield: 96.0%

1-Chloro-4-iodobenzene (637-87-6) + 2-benzyl-6-chloropyridazin-3(2H)-one (50500-58-8) → 2-benzyl-6-chloro-4-(4-chlorophenyl)pyridazin-3(2H)-one (1345839-60-2)

Guidance literature:

2-benzyl-6-chloropyridazin-3(2H)-one; In tetrahydrofuran; at 20 ℃; for 0.00305556h; Inert atmosphere;

1-Chloro-4-iodobenzene; With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/jo201587j

upstream raw materials:

6-chloro-2H-pyridazin-3-one

benzyl bromide

Downstream raw materials:

C₂₀H₁₆N₂O₂

2-benzyl-6-(3-methylbut-1-ynyl)pyridazin-3(2H)-one

2-benzyl-6-(6-methoxypyridine-3-yl)-2H-pyridazine-3-one

2-benzylpyridazin-3(2H)-one