Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(hydrogen phosphonate)

Base Information

• Chemical Name: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(hydrogen phosphonate)
• CAS No.: 50571-26-1
• Molecular Formula: C31H33N2O9P
• Molecular Weight: 608.585
• Mol file: 50571-26-1.mol

Synonyms:

Chemical Property of Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(hydrogen phosphonate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(hydrogen phosphonate)

There total 19 articles about Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(hydrogen phosphonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → 5'-O-dimethoxytritylthymidine 3'-H-phosphonate (50571-26-1)

Guidance literature:

With 1H-imidazole; phosphorus trichloride; In acetonitrile; for 2h;

DOI:10.1016/S0040-4039(00)88833-4

Reference yield:

C35H37N2O11P → 5'-O-dimethoxytritylthymidine 3'-H-phosphonate (50571-26-1)

Guidance literature:

With water; In pyridine; at 20 ℃; for 10h; Yield given;

DOI:10.1016/S0040-4039(00)84611-0

Reference yield:

1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(4-oxo-4H-benzo[1,3,2]dioxaphosphinin-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione → 5'-O-dimethoxytritylthymidine 3'-H-phosphonate (50571-26-1)

Guidance literature:

With water; In pyridine; Yield given;

DOI:10.1016/S0040-4039(00)84611-0

upstream raw materials:

C₃₄H₃₇N₂O₉P

5′-O-(4,4′-dimethoxytrityl)thymidine-3′-O-[2-cyanoethyl]phosphonate

Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester bis-(2,2,2-trifluoro-1-trifluoromethyl-ethyl) ester

5'-O-(4-4'-dimethoxytrityl)thymidine

Downstream raw materials:

C₄₈H₄₉N₄O₁₄P

C₃₆H₄₁N₂O₁₀P

3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl ethyl phosphonate

triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate