Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[bis[2,2,2-trifluoro-1-(trifluoromethyl)ethyl] phosphite]

Base Information

• Chemical Name: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[bis[2,2,2-trifluoro-1-(trifluoromethyl)ethyl] phosphite]
• CAS No.: 120942-89-4
• Molecular Formula: C37H33F12N2O9P
• Molecular Weight: 908.632
• Mol file: 120942-89-4.mol

Synonyms:

Chemical Property of Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[bis[2,2,2-trifluoro-1-(trifluoromethyl)ethyl] phosphite]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[bis[2,2,2-trifluoro-1-(trifluoromethyl)ethyl] phosphite]

There total 1 articles about Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[bis[2,2,2-trifluoro-1-(trifluoromethyl)ethyl] phosphite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

tris(1,1,1,3,3,3-hexafluoroisopropyl)phosphite (66470-81-3) + 5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester bis-(2,2,2-trifluoro-1-trifluoromethyl-ethyl) ester (120942-89-4)

Guidance literature:

With pyridine; In dichloromethane; for 0.25h;

DOI:10.1021/ja00191a056

Reference yield: 89.0%

Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester bis-(2,2,2-trifluoro-1-trifluoromethyl-ethyl) ester (120942-89-4) + 3'-O-benzoylthymidine (17331-53-2) → C48H49N4O14P (102987-86-0)

Guidance literature:

With 1-methyl-1H-imidazole; water; In acetonitrile; for 0.166667h;

DOI:10.1021/ja00191a056

Reference yield: 89.0%

Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester bis-(2,2,2-trifluoro-1-trifluoromethyl-ethyl) ester (120942-89-4) → C34H33F6N2O8PS (142941-94-4)

Guidance literature:

With hydrogen sulfide; In tetrahydrofuran; for 0.5h;

DOI:10.1246/cl.1992.935

upstream raw materials:

tris(1,1,1,3,3,3-hexafluoroisopropyl)phosphite

5'-O-(4-4'-dimethoxytrityl)thymidine

Downstream raw materials:

C₃₄H₃₃F₆N₂O₈PS

5'-O-dimethoxytritylthymidine 3'-H-phosphonate

C₄₈H₄₉N₄O₁₄P

Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O'-(2,2,2-trifluoro-1-trifluoromethyl-ethyl) ester