2-Butenoic acid, 2-[[(phenylmethoxy)carbonyl]amino]-, ethyl ester, (Z)-

Base Information

• Chemical Name: 2-Butenoic acid, 2-[[(phenylmethoxy)carbonyl]amino]-, ethyl ester, (Z)-
• CAS No.: 50685-03-5
• Molecular Formula: C14H17NO4
• Molecular Weight: 263.28900
• Mol file: 50685-03-5.mol

Synonyms:N-Carbobenzoxy-2,3-dihydro-butysinaethylester;(Z)-2-Benzyloxycarbonylamino-but-2-enoic acid ethyl ester;

Chemical Property of 2-Butenoic acid, 2-[[(phenylmethoxy)carbonyl]amino]-, ethyl ester, (Z)-

Chemical Property:

• PSA: 64.63000
• LogP: 2.77060

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Butenoic acid, 2-[[(phenylmethoxy)carbonyl]amino]-, ethyl ester, (Z)-

There total 8 articles about 2-Butenoic acid, 2-[[(phenylmethoxy)carbonyl]amino]-, ethyl ester, (Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

amino-crotonic acid ethyl ester (71385-53-0) + benzyl chloroformate (501-53-1,94274-21-2) → ethyl (Z)-2-(N-benzyloxycarbonylamino)-2-butenoate (50685-03-5)

Guidance literature:

With pyridine; hydrogenchloride; In diethyl ether; for 6h; Ambient temperature;

DOI:10.1246/bcsj.53.2905

Reference yield: 78.0%

acetaldehyde (75-07-0,9002-91-9) + ethyl benzyloxycarbonylamino(toluene-4-sulfonyl)acetate (295365-34-3) → ethyl 2-(N-benzyloxycarbonylamino)-2-butenoate (50685-02-4,50685-03-5)

Guidance literature:

With tributylphosphine; tetrabutylammomium bromide; sodium carbonate; In tetrahydrofuran; at 20 ℃;

DOI:10.1246/bcsj.75.2517

Reference yield: 69.0%

Ethyl 2-oxobutanoate (15933-07-0) + O-benzyl carbamate (621-84-1) → ethyl (Z)-2-(N-benzyloxycarbonylamino)-2-butenoate (50685-03-5)

Guidance literature:

With trichlorophosphate; In benzene; for 4h; Heating;

DOI:10.1246/bcsj.53.2905

upstream raw materials:

acetaldehyde

ethyl 2-isothiocyanatoacetate

benzyl chloroformate

Ethyl 2-oxobutanoate

Downstream raw materials:

Cbz-(Z)-ΔBut-Gly-OEt

(Z)-2-(benzyloxycarbonylamino)but-2-enoic acid