1-Acetyl-carboline

Base Information

• Chemical Name: 1-Acetyl-carboline
• CAS No.: 50892-83-6
• Molecular Formula: C13H10N2O
• Molecular Weight: 210.2313
• Hs Code.: 2933990090
• Mol file: 50892-83-6.mol

Synonyms:1-(9H-β-Carbolin-1-yl)ethanone;

Chemical Property of 1-Acetyl-carboline

Chemical Property:

• Boiling Point: 438.2 °C at 760 mmHg
• Flash Point: 219.3 °C
• PSA: 45.75000
• Density: 1.307 g/cm³
• LogP: 2.91870

Purity/Quality:

99% ^*data from raw suppliers

1-(9H-pyrido[3,4-b]indol-1-yl)-Ethanone 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• General Description: 1-Acetyl-carboline, also known as 1-(9H-β-Carbolin-1-yl)ethanone, is a β-carboline derivative that serves as a key intermediate in the synthesis of bioactive compounds, such as anticancer and antibacterial agents. It undergoes regioselective acetylation at the 1-position and is utilized in the preparation of chalcone derivatives, which exhibit notable cytotoxic activity against human tumor cell lines. Additionally, its structural framework is relevant in enzymatic pathways, such as the marinacarboline biosynthesis, where it contributes to the formation of the β-carboline core.

Technology Process of 1-Acetyl-carboline

There total 14 articles about 1-Acetyl-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-acetyl-3,4-dihydro-β-carboline (934463-33-9) → 1-(9H-β-carbolin-1-yl)-ethanone (50892-83-6)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 25 ℃; for 0.5h;

DOI:10.1002/ejoc.201300080

Reference yield: 79.0%

betacarboline (244-63-3) + acetaldehyde (75-07-0,9002-91-9) → 1-(9H-β-carbolin-1-yl)-ethanone (50892-83-6)

Guidance literature:

With tert.-butylhydroperoxide; sulfuric acid; iron(II) sulfate; In water; acetic acid; at 0 ℃; for 0.5h;

DOI:10.1080/00397919508011768

Reference yield: 70.0%

1-ethyl-9H-β-carboline (20127-61-1) → 1-(9H-β-carbolin-1-yl)-ethanone (50892-83-6)

Guidance literature:

With tetrabutylammomium bromide; In 1,4-dioxane; at 70 ℃; for 26h; Irradiation;

upstream raw materials:

tributyl(1-ethoxyvinyl)stannane

1-Chlor-9H-pyrido<3,4-b>indol

methyl 1-ethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

1-(1-ethoxyvinyl)-9H-pyrido[3,4-b]indole

Downstream raw materials:

9H-pyrido[3,4-b]indole-1-carboxamide