Cinepazide maleate

Base Information

Chemical Name:Cinepazide maleate
CAS No.:28044-44-2
Deprecated CAS:53529-16-1
Molecular Formula:C₄H₄O₄*C₂₂H₃₁N₃O₅
Molecular Weight:533.579
Hs Code.:
European Community (EC) Number:247-613-1,248-795-5
NSC Number:291562
UNII:Y35B3VA60V
Wikidata:Q27294204
ChEMBL ID:CHEMBL4303265
Mol file:28044-44-2.mol

Synonyms:1-((1-pyrrolidinylcarbonyl)methyl)-4-(3,4,5-trimethoxycinnamoyl)piperazine;1-((1-pyrrolidynylcarbonyl)methyl)-4-(3,4,5-trimethoxycinnamoyl)piperazine maleate;67350-MD;cinepazide;cinepazide maleate;MD-67350 free base;Vasodistal

Suppliers and Price of Cinepazide maleate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Cinepazide maleate

Chemical Property:

Boiling Point:637.8°Cat760mmHg
Flash Point:339.5°C
Density:g/cm³
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:9
Exact Mass:533.23732970
Heavy Atom Count:38
Complexity:705

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCN(CC2)CC(=O)N3CCCC3.C(=CC(=O)O)C(=O)O
Isomeric SMILES:COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCN(CC2)CC(=O)N3CCCC3.C(=C\C(=O)O)\C(=O)O
Recent ClinicalTrials:Clinical Study of Cinepazide Maleate Injection in the Treatment of Acute Ischemic Stroke

Technology Process of Cinepazide maleate

There total 3 articles about Cinepazide maleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 90892-09-4
bromoacetopyrrolidine

: 88053-13-8
N-(3,4,5-trimethoxy cinnamoyl)-piperazine

: 110-16-7,26099-09-2
maleic acid

: 28044-44-2
cinepazide maleate

Guidance literature:: N-(3,4,5-trimethoxy cinnamoyl)-piperazine; With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetone; for 0.5h;

bromoacetopyrrolidine; In acetone; at 20 ℃; for 3h;

maleic acid; In ethanol; for 0.5h; Reflux;

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 28044-44-2
cinepazide maleate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 3 h / 20 °C / Inert atmosphere

2.1: lithium hydroxide; water / tetrahydrofuran / 5 h / 0 - 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.33 h / 20 °C

3.2: 5 h / 0 - 20 °C

4.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetone / 0.5 h

4.2: 3 h / 20 °C

4.3: 0.5 h / Reflux

With water; tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane; acetone; toluene;

Reference yield:

: 1878-29-1,30273-65-5,31892-98-5
ethyl (E)-3-(3,4,5-trimethoxyphenyl)acrylate

: 28044-44-2
cinepazide maleate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 5 h / 0 - 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.33 h / 20 °C

2.2: 5 h / 0 - 20 °C

3.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetone / 0.5 h

3.2: 3 h / 20 °C

3.3: 0.5 h / Reflux

With water; tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane; acetone;