8-METHYL-3,8-DIAZABICYCLO[3.2.1]OCTANE

Base Information

• Chemical Name: 8-METHYL-3,8-DIAZABICYCLO[3.2.1]OCTANE
• CAS No.: 51102-42-2
• Molecular Formula: C7H14N2
• Molecular Weight: 126.202
• Hs Code.: 2933990090
• Mol file: 51102-42-2.mol

Synonyms:3-azatropane;8-metil-3,8-diazabiciclo<3,2,1>ottano;

Chemical Property of 8-METHYL-3,8-DIAZABICYCLO[3.2.1]OCTANE

Chemical Property:

• Boiling Point: 115-116 °C(Press: 40 Torr)
• PKA: 10.05±0.20(Predicted)
• PSA: 15.27000
• Density: 0.970±0.06 g/cm3(Predicted)
• LogP: 0.31910

Purity/Quality:

NLT 98% ^*data from raw suppliers

8-Methyl-3,8-diaza-bicyclo[3.2.1]octane 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-METHYL-3,8-DIAZABICYCLO[3.2.1]OCTANE

There total 13 articles about 8-METHYL-3,8-DIAZABICYCLO[3.2.1]OCTANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-benzyl-8-methyl-3,8-diazabicyclo[3.2.1]octane (17783-48-1) → 8-methyl-3,8-diazabicyclo[3,2,1]octane (51102-42-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 24h;

Reference yield: 77.0%

8-methyl-3,8-diazabicyclo[3.2.1]octan-2-one (22315-26-0) → 8-methyl-3,8-diazabicyclo[3,2,1]octane (51102-42-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 6h; Heating;

DOI:10.1016/j.tetlet.2006.11.141

Reference yield:

3-benzyl-2,4-dioxo-8-methyl-3,8-diazabicyclo-(3.2.1)octane (17783-46-9) → 8-methyl-3,8-diazabicyclo[3,2,1]octane (51102-42-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / AlH₃ / tetrahydrofuran / 0 °C

2: H₂ / 10percent Pd/C / ethanol

With aluminium hydride; hydrogen; 10percent Pd/C; In tetrahydrofuran; ethanol;

DOI:10.1021/jm000300r

upstream raw materials:

3-benzyl-8-methyl-3,8-diazabicyclo[3.2.1]octane

8-methyl-3,8-diazabicyclo[3.2.1]octan-2-one

(S)-methyl 1-methyl-5-oxopyrrolidine-2-carboxylate

3-benzyl-2,4-dioxo-8-methyl-3,8-diazabicyclo-(3.2.1)octane

Downstream raw materials:

3-benzhydryl-8-methyl-3,8-diaza-bicyclo[3.2.1]octane

3-(4-chloro-3-methoxy-phenyl)-7-[4-(8-methyl-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-phenyl]-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine

C₃₁H₃₀N₆O

N-[3(R,S)-2,3-Dihydro-5-(8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-oxo-1-propyl-1H-1,4-benzodiazepin-3-yl]-N'-[3-methylphenyl]urea

Refernces

• 1、 -. "BIS-HETEROARYL DERIVATIVES AS MODULATORS OF PROTEIN AGGREGATION". Paragraph 0162. . Retrieved 2017/02/24.
• 2、 -. "NOVEL DIAZABICYCLIC ARYL DERIVATIVES AND THEIR MEDICAL USE". Page/Page column 20. . Retrieved 2008/06/13.