methyl 2-hydroxy-4-phenylmethoxy-benzoate

Base Information

• Chemical Name: methyl 2-hydroxy-4-phenylmethoxy-benzoate
• CAS No.: 5427-29-2
• Molecular Formula: C15H14 O4
• Molecular Weight: 258.274
• Hs Code.: 2918990090
• Mol file: 5427-29-2.mol

Synonyms:Salicylicacid, 4-(benzyloxy)-, methyl ester (6CI,8CI); 4-Benzyloxy-2-hydroxybenzoic acidmethyl ester; Methyl 2-hydroxy-4-benzyloxybenzoate; Methyl4-benzyloxy-2-hydroxybenzoate; NSC 14990

Chemical Property of methyl 2-hydroxy-4-phenylmethoxy-benzoate

Chemical Property:

• Vapor Pressure: 3.94E-07mmHg at 25°C
• Melting Point: 102-104 °C
• Boiling Point: 404.8°C at 760 mmHg
• PKA: 9.38±0.10(Predicted)
• Flash Point: 150.7°C
• PSA: 55.76000
• Density: 1.227g/cm³
• LogP: 2.75780
• Solubility.: Chloroform; Acetone

Purity/Quality:

97% ^*data from raw suppliers

2-Hydroxy-4-(phenylmethoxy)benzoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Hydroxy-4-(phenylmethoxy)benzoic Acid Methyl Ester is an intermediate used in the synthesis of 4-Hydroxy Flecainide (H942485), which is an analogue of Flecainide (F390000).

Technology Process of methyl 2-hydroxy-4-phenylmethoxy-benzoate

There total 13 articles about methyl 2-hydroxy-4-phenylmethoxy-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 4-benzyloxy-2-methoxymethyloxybenzoate (422566-44-7) → methyl 2-hydroxy-4-benzyloxybenzoate (5427-29-2)

Guidance literature:

With silica-immobilized p-TsOH; In toluene; at 20 ℃; for 0.42h;

DOI:10.1016/j.tet.2009.03.089

Reference yield: 98.0%

methyl 2,4-bis(benzyloxy)benzoate (85593-76-6) → methyl 2-hydroxy-4-benzyloxybenzoate (5427-29-2)

Guidance literature:

With methanol; silica-immobilized p-TsOH; In toluene; at 80 ℃; for 4.5h;

DOI:10.1016/j.tet.2009.03.089

Reference yield: 95.0%

methyl 2,4-dihydroxybenzoate (2150-47-2) + benzyl bromide (100-39-0) → methyl 2-hydroxy-4-benzyloxybenzoate (5427-29-2)

Guidance literature:

methyl 2,4-dihydroxybenzoate; With potassium carbonate; In acetone; at 0 - 20 ℃; for 1h;

benzyl bromide; In acetone; at 0 ℃; Temperature; Reflux;

upstream raw materials:

methyl 2,4-dihydroxybenzoate

benzyl chloride

benzyl bromide

potassium carbonate

Downstream raw materials:

4-benzyloxy-5-bromo-2-hydroxy-benzoic acid methyl ester

4-(benzyloxy)-2-hydroxybenzoic acid

methyl 4-benzyloxy-2-methoxybenzoate

methyl 4-benzyloxy-2-methoxymethyloxybenzoate