Methyl 3-(naphthalen-2-yl)but-2-enoate

Base Information

Chemical Name:Methyl 3-(naphthalen-2-yl)but-2-enoate
CAS No.:51212-51-2
Molecular Formula:C₁₅H₁₄O₂
Molecular Weight:226.275
Hs Code.:
DSSTox Substance ID:DTXSID20711424
Mol file:51212-51-2.mol

Synonyms:51212-51-2;Methyl 3-(naphthalen-2-yl)but-2-enoate;DTXSID20711424;C12358

Suppliers and Price of Methyl 3-(naphthalen-2-yl)but-2-enoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 3-(naphthalen-2-yl)but-2-enoate

Chemical Property:

XLogP3:4.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:226.099379685
Heavy Atom Count:17
Complexity:306

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=CC(=O)OC)C1=CC2=CC=CC=C2C=C1

Technology Process of Methyl 3-(naphthalen-2-yl)but-2-enoate

There total 2 articles about Methyl 3-(naphthalen-2-yl)but-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 623-43-8
crotonic acid methyl ester

: 580-13-2
2-bromonaphthalene

: 51212-51-2
methyl (Z)-3-(naphthalen-2-yl)-but-2-enoate

: 212078-20-1
methyl (E)-3-(naphthalen-2-yl)-but-2-enoate

Guidance literature:: With N-Methyldicyclohexylamine; tetraethylammonium chloride; palladium diacetate; In N,N-dimethyl acetamide; at 95 - 100 ℃; for 16h;
DOI:10.1002/(SICI)1521-3765(19991105)5:11<3107::AID-CHEM3107>3.0.CO;2-#

Reference yield:

: 116-54-1
dichloroacetic acid methyl ester

: 93-08-3
methyl 2-naphthyl ketone

: 51212-51-2
methyl (Z)-3-(naphthalen-2-yl)-but-2-enoate

: 212078-20-1
methyl (E)-3-(naphthalen-2-yl)-but-2-enoate

Guidance literature:: With chromium dichloride; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1016/S0960-894X(03)00101-X

Reference yield:

: 51212-51-2
methyl (Z)-3-(naphthalen-2-yl)-but-2-enoate

: 565190-73-0
N-(2-carbomethoxyphenyl)-3-(naphthalen-2-yl)-but-2(Z)-enamide

Guidance literature:: Multi-step reaction with 3 steps

1: aq. LiOH / tetrahydrofuran / 12 h / 20 °C

2: SOCl₂; DMF / 2 h / Heating

3: pyridine / diethyl ether / 5 h / 20 °C

With pyridine; lithium hydroxide; thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether;
DOI:10.1016/S0960-894X(03)00101-X