Chemical Property of (E)-2-(3-(naphthalen-2-yl)but-2-enamido)benzoic acid
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Refractive Index:1.698
- Boiling Point:600.607 °C at 760 mmHg
- PKA:3.46±0.36(Predicted)
- Flash Point:317.036 °C
- PSA：66.40000
- Density:1.285 g/cm3
- LogP:4.65300
- Storage Temp.:Store at RT
- Solubility.:DMSO (Slightly), Methanol (Slightly, Sonicated)
- XLogP3:5.1
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:4
- Exact Mass:331.12084340
- Heavy Atom Count:25
- Complexity:527
- Purity/Quality:
-
99%, *data from raw suppliers
BIBR 1532 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(=CC(=O)NC1=CC=CC=C1C(=O)O)C2=CC3=CC=CC=C3C=C2
- Isomeric SMILES:C/C(=C\C(=O)NC1=CC=CC=C1C(=O)O)/C2=CC3=CC=CC=C3C=C2
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Description
BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase (IC50 = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT. Through its effects on telomerase, BIBR 1532 induces senescence or apoptosis in cancer cells. Apoptosis in triple negative breast cancer cells induced by BIBR 1532 is potentiated by glucose restriction.
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Uses
BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT.
