(R)-Epibromohydrine

Base Information

• Chemical Name: (R)-Epibromohydrine
• CAS No.: 51594-57-1
• Molecular Formula: C3H5BrO
• Molecular Weight: 136.976
• Hs Code.: 2910900090
• Mol file: 51594-57-1.mol

Synonyms:

Chemical Property of (R)-Epibromohydrine

Chemical Property:

• Boiling Point: 138 °C
• PSA: 12.53000
• Density: 1.744±0.06 g/cm3(Predicted)
• LogP: 0.78010

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-Epibromohydrine

There total 8 articles about (R)-Epibromohydrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,2-Epoxy-3-bromopropane (3132-64-7,82584-73-4) → (S)-(+)-3-bromo-1,2-propanediol (137490-63-2) + (R)-3-bromo-1,2-epoxypropane (51594-57-1,82584-73-4)

Guidance literature:

With (S,S)-[N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino]cobalt(III) acetate; water; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/ja016737l

Reference yield: 90.0%

1,2-Epoxy-3-bromopropane (3132-64-7,82584-73-4) → (S)-(+)-3-bromo-1,2-propanediol (137490-63-2) + (R)-3-bromo-1,2-epoxypropane (51594-57-1,82584-73-4) + 1-bromo-2,3-epoxypropane (96479-96-8,82584-73-4)

Guidance literature:

With (S,S)-[N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino]cobalt(III) acetate; water; In tetrahydrofuran; at 0 ℃;

DOI:10.1021/ja016737l

Reference yield: 90.0%

1,2-Epoxy-3-bromopropane (3132-64-7,82584-73-4) → (2R)-3-bromo-1,2-propanediol (14437-88-8) + (R)-3-bromo-1,2-epoxypropane (51594-57-1,82584-73-4) + 1-bromo-2,3-epoxypropane (96479-96-8,82584-73-4)

Guidance literature:

With [(R,R)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminato^(2-)]cobalt(III) acetate; water; In tetrahydrofuran; at 0 ℃;

DOI:10.1021/ja016737l

upstream raw materials:

Toluene-4-sulfonic acid (R)-3-bromo-2-hydroxy-propyl ester

1,2-Epoxy-3-bromopropane

(2S)-2,3-dibromopropan-1-ol

1,3-dibromo-2-hydroxypropane

Refernces

• 1、 Xie, Sheng-Ming,Fu, Nan,Li, Li,Yuan, Bao-Yan,Zhang, Jun-Hui,Li, Yan-Xia,Yuan, Li-Ming. "Homochiral Metal-Organic Cage for Gas Chromatographic Separations". . p. 9182 - 9188. Retrieved 2018/07/21.
• 2、 Prokop, Zbynek,Sato, Yukari,Brezovsky, Jan,Mozga, Tomas,Chaloupkova, Radka,Koudelakova, Tana,Jerabek, Petr,Stepankova, Veronika,Natsume, Ryo,Van Leeuwen, Jan G. E.,Janssen, Dick B.,Florian, Jan,Nagata, Yuji,Senda, Toshiya,Damborsky, Jiri. "Enantioselectivity of haloalkane dehalogenases and its modulation by surface loop engineering". supporting information; experimental part. p. 6111 - 6115. Retrieved 2010/11/05.