4-[4-(Benzyloxy)phenoxy]-6,7-dimethoxyquinoline

Base Information

Chemical Name:4-[4-(Benzyloxy)phenoxy]-6,7-dimethoxyquinoline
CAS No.:516526-36-6
Molecular Formula:C24H21NO4
Molecular Weight:387.435
Hs Code.:
DSSTox Substance ID:DTXSID80590838
Wikidata:Q82484463
Mol file:516526-36-6.mol

Synonyms:516526-36-6;4-[4-(benzyloxy)phenoxy]-6,7-dimethoxyquinoline;SCHEMBL4465629;DTXSID80590838

Suppliers and Price of 4-[4-(Benzyloxy)phenoxy]-6,7-dimethoxyquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-[4-(Benzyloxy)phenoxy]-6,7-dimethoxyquinoline

Chemical Property:

XLogP3:5.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:387.14705815
Heavy Atom Count:29
Complexity:476

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)OCC4=CC=CC=C4

Technology Process of 4-[4-(Benzyloxy)phenoxy]-6,7-dimethoxyquinoline

There total 5 articles about 4-[4-(Benzyloxy)phenoxy]-6,7-dimethoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 35654-56-9
6,7-dimethoxy-4-chloroquinoline

: 103-16-2
4-Benzyloxyphenol

: 516526-36-6
4-(4-(benzyloxy)phenoxy)-6,7-dimethoxyquinoline

Guidance literature:: In chlorobenzene; Heating / reflux;

Reference yield:

: 13436-14-1,120372-85-2
ethyl 6,7-dimethoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylate

: 516526-36-6
4-(4-(benzyloxy)phenoxy)-6,7-dimethoxyquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / methanol / 1 h / Heating

2: 2.3 g / diphenyl ether / 1 h / 280 °C

3: 8 percent / POCl₃ / 0.5 h / Heating

4: 32 percent / 0.33 h / 170 °C

With sodium hydroxide; trichlorophosphate; In methanol; diphenylether;
DOI:10.1016/j.bmc.2003.08.020

Reference yield:

: 6315-89-5
3,4-dimethoxyaniline

: 516526-36-6
4-(4-(benzyloxy)phenoxy)-6,7-dimethoxyquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1 h / 120 °C

1.2: 66 percent / diphenyl ether / 1 h / 280 °C

2.1: aq. NaOH / methanol / 1 h / Heating

3.1: 2.3 g / diphenyl ether / 1 h / 280 °C

4.1: 8 percent / POCl₃ / 0.5 h / Heating

5.1: 32 percent / 0.33 h / 170 °C

With sodium hydroxide; trichlorophosphate; In methanol; diphenylether;
DOI:10.1016/j.bmc.2003.08.020