1-Benzyl-5-oxopyrrolidine-2-carbonitrile

Base Information

Chemical Name:1-Benzyl-5-oxopyrrolidine-2-carbonitrile
CAS No.:51685-38-2
Molecular Formula:C12H12N2O
Molecular Weight:200.24
Hs Code.:
DSSTox Substance ID:DTXSID50525071
Mol file:51685-38-2.mol

Synonyms:1-Benzyl-5-oxopyrrolidine-2-carbonitrile;51685-38-2;DTXSID50525071

Suppliers and Price of 1-Benzyl-5-oxopyrrolidine-2-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Benzyl-5-oxopyrrolidine-2-carbonitrile

Chemical Property:

XLogP3:1.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:200.094963011
Heavy Atom Count:15
Complexity:285

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)N(C1C#N)CC2=CC=CC=C2

Technology Process of 1-Benzyl-5-oxopyrrolidine-2-carbonitrile

There total 10 articles about 1-Benzyl-5-oxopyrrolidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 151-50-8
potassium cyanide

: 88461-15-8
1-benzyl-5-oxopyrrolidin-2-yl acetate

: 51685-38-2
5-cyano-1-(phenylmethyl)-2-pyrrolidinone

Guidance literature:: In dimethyl sulfoxide; at 75 ℃; for 4h;

Reference yield:

: 1-benzylpyrrolidine-2,5-dicarbonitrile

: 588-46-5
N-(phenylmethyl)acetamide

: 51685-38-2
5-cyano-1-(phenylmethyl)-2-pyrrolidinone

Guidance literature:: With water; In N,N-dimethyl-formamide; at 30 ℃; for 120h; Microbiological reaction;
DOI:10.1016/j.molcatb.2010.11.006

Reference yield:

: 2142-06-5
1-(phenylmethyl)-2,5-pyrrolidinedione

: 51685-38-2
5-cyano-1-(phenylmethyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄/H⁽¹⁺⁾ / 0 °C

2: 96 h

3: dimethylformamide / 18 h / 75 °C

With sodium tetrahydroborate; hydrogen cation; In N,N-dimethyl-formamide;