1-(4-methoxyphenyl)-2-phenyl-1H-indole

Base Information

• Chemical Name: 1-(4-methoxyphenyl)-2-phenyl-1H-indole
• CAS No.: 52351-44-7
• Molecular Formula: C21H17NO
• Molecular Weight: 299.372
• DSSTox Substance ID: DTXSID50573390
• Nikkaji Number: J1.318.784C
• Wikidata: Q82462106
• Mol file: 52351-44-7.mol

Synonyms:1-(4-methoxyphenyl)-2-phenyl-1H-indole;52351-44-7;SCHEMBL1077378;DTXSID50573390;XSBFESFZMJIJHS-UHFFFAOYSA-N;1-(4-Methoxy-phenyl)-2-phenyl-1H-indole

Chemical Property of 1-(4-methoxyphenyl)-2-phenyl-1H-indole

Chemical Property:

• XLogP3: 5.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 299.131014166
• Heavy Atom Count: 23
• Complexity: 370

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)N2C3=CC=CC=C3C=C2C4=CC=CC=C4

Technology Process of 1-(4-methoxyphenyl)-2-phenyl-1H-indole

There total 9 articles about 1-(4-methoxyphenyl)-2-phenyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-bromo-2-(phenylethenyl)benzene (21375-88-2) + 4-methoxy-aniline (104-94-9) → 1-(4-methoxy-phenyl)-2-phenyl-1H-indole (52351-44-7)

Guidance literature:

1-bromo-2-(phenylethenyl)benzene; 4-methoxy-aniline; With 1,1'-bis-(diphenylphosphino)ferrocene; bis(1,5-cyclooctadiene)nickel⁽⁰⁾; sodium t-butanolate; In toluene; at 20 - 105 ℃; Inert atmosphere; Combinatorial reaction / High throughput screening (HTS);

With potassium tert-butylate; In toluene; at 20 - 120 ℃; Inert atmosphere; Combinatorial reaction / High throughput screening (HTS);

DOI:10.1016/j.jorganchem.2010.08.047

Reference yield: 91.0%

2-phenyl-indole (948-65-2) + 4-chloromethoxybenzene (623-12-1) → 1-(4-methoxy-phenyl)-2-phenyl-1H-indole (52351-44-7)

Guidance literature:

With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; sodium t-butanolate; In toluene; at 110 ℃; for 12h; Inert atmosphere; Glovebox;

DOI:10.1002/chem.201302453

Reference yield: 88.0%

2-phenyl-indole (948-65-2) + para-iodoanisole (696-62-8) → 1-(4-methoxy-phenyl)-2-phenyl-1H-indole (52351-44-7)

Guidance literature:

With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine; In toluene; at 110 ℃; Inert atmosphere;

upstream raw materials:

1-bromo-4-methoxy-benzene

2-phenyl-indole

4-methoxy-N-(1-phenylethylidene)benzenamine

2,3-dibromobenzene

Downstream raw materials:

11-(4-methxohyphenyl)-6-methyl-11H-benzo[a]carbazole

C₂₈H₂₃NO

3-bromo-1-(4-methoxyphenyl)-2-phenyl-1H-indole

1-(4-methoxyphenyl)-2-phenyl-3-(thiophen-2-yl)-1H-indole