2-Ethyl-3-phenylquinazolin-4-one

Base Information

• Chemical Name: 2-Ethyl-3-phenylquinazolin-4-one
• CAS No.: 5260-41-3
• Molecular Formula: C16H14N2O
• Molecular Weight: 250.3
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60352138
• Nikkaji Number: J3.666.511D
• Wikidata: Q82129135
• ChEMBL ID: CHEMBL2259661
• Mol file: 5260-41-3.mol

Synonyms:2-ethyl-3-phenylquinazolin-4-one;5260-41-3;2-ethyl-3-phenylquinazolin-4(3H)-one;2-ethyl-3-phenyl-4(3H)-quinazolinone;ephinazone;Oprea1_074371;Oprea1_691001;SCHEMBL8242227;CHEMBL2259661;2-ethyl-3-phenyl-4-quinazolone;DTXSID60352138;CCG-19682;STL302942;AKOS003218649;4(3h)-quinazolinone,2-ethyl-3-phenyl-;EU-0077110;2-ethyl-3-phenyl-3,4-dihydroquinazolin-4-one;SR-01000482934;SR-01000482934-1

Chemical Property of 2-Ethyl-3-phenylquinazolin-4-one

Chemical Property:

• PSA: 34.89000
• LogP: 2.94810
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 250.110613074
• Heavy Atom Count: 19
• Complexity: 371

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3

Technology Process of 2-Ethyl-3-phenylquinazolin-4-one

There total 22 articles about 2-Ethyl-3-phenylquinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-aminobenzanilide (4424-17-3) + Triethyl orthopropionate (115-80-0) → 2-ethyl-3-phenyl-3H-quinazolin-4-one (5260-41-3)

Guidance literature:

With acetic acid; In ethanol; at 110 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.3390/molecules23112925

Reference yield: 88.0%

aniline (62-53-3) + 2-(propionylamino)benzoic acid (19165-26-5) → 2-ethyl-3-phenyl-3H-quinazolin-4-one (5260-41-3)

Guidance literature:

With phosphorus trichloride; In toluene; at 130 ℃; for 5h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02723

Reference yield: 69.0%

ethylmagnesium bromide (925-90-6) + 1-phenyl-3-(2-ethoxycarbonylphenyl) carbodiimide (622403-42-3) → 2-ethyl-3-phenyl-3H-quinazolin-4-one (5260-41-3)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃; for 3h;

DOI:10.1055/s-0032-1316773

upstream raw materials:

N-propionyl-anthranilic acid anilide

N-(2-benzoylphenyl)propionamide

aniline

2-(propionylamino)benzoic acid

Downstream raw materials:

2-ethyl-4,4-diphenyl-4H-benzo[d][1,3]oxazine

3-phenyl-2-ethylquinazoline-4(3H)-thione

2-[1-(2-dimethylamino-ethylamino)-ethyl]-3-phenyl-3H-quinazolin-4-one

2-(1-bromoethyl)-3-phenylquinazolin-4(3H)-one

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