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CAS No.: | 5260-41-3 |
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Name: | 4(3H)-Quinazolinone, 2-ethyl-3-phenyl- |
Article Data: | 17 |
Cas Database | |
Molecular Structure: | |
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Formula: | C16H14N2O |
Molecular Weight: | 250.3 |
PSA: | 34.89000 |
LogP: | 2.94810 |
2-aminobenzanilide
Triethyl orthopropionate
2-ethyl-3-phenyl-3H-quinazolin-4-one
Conditions | Yield |
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With acetic acid In ethanol at 110℃; for 24h; Inert atmosphere; Sealed tube; | 92% |
ethylmagnesium bromide
1-phenyl-3-(2-ethoxycarbonylphenyl) carbodiimide
2-ethyl-3-phenyl-3H-quinazolin-4-one
Conditions | Yield |
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In tetrahydrofuran at -78 - 20℃; for 3h; | 69% |
A
2-ethyl-3-phenyl-3H-quinazolin-4-one
Conditions | Yield |
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With sodium tetrahydroborate; (R)-DTBM-SEGPHOS; palladium diacetate In N,N-dimethyl-formamide at 0℃; for 21h; Inert atmosphere; enantioselective reaction; | A 45% B 35% C n/a |
2-ethyl-benzo[d][1,3]oxazin-4-one
aniline
2-ethyl-3-phenyl-3H-quinazolin-4-one
Conditions | Yield |
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With trichlorophosphate In dichloromethane for 4h; Heating; | 42% |
N-propionyl-anthranilic acid anilide
2-ethyl-3-phenyl-3H-quinazolin-4-one
Conditions | Yield |
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at 250℃; |
N-(2-benzoylphenyl)propionamide
2-ethyl-3-phenyl-3H-quinazolin-4-one
Conditions | Yield |
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With sodium azide; chloroform; sulfuric acid |
Conditions | Yield |
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With phosphorus trichloride | |
With phosphorus trichloride In toluene | |
With phosphorus trichloride In toluene at 110℃; |
Conditions | Yield |
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Multi-step reaction with 2 steps 1: 82 percent / 4 h / Heating 2: 42 percent / phosphorus oxychloride / CH2Cl2 / 4 h / Heating View Scheme |
Conditions | Yield |
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Multi-step reaction with 2 steps 1: 76 percent / dimethylformamide 2: PCl3 / toluene View Scheme | |
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 2 h / 0 °C 2: phosphorus trichloride / toluene / 110 °C View Scheme |
2-ethyl-3-phenyl-3H-quinazolin-4-one
Conditions | Yield |
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Multi-step reaction with 2 steps 1: potassium iodide / ethanol; water / 6 h / 20 °C 2: piperidine / 20 - 50 °C View Scheme |