3-Amino-2-chloro-6-picoline

Base Information

Chemical Name:3-Amino-2-chloro-6-picoline
CAS No.:39745-40-9
Molecular Formula:C6H7ClN2
Molecular Weight:142.588
Hs Code.:29339900
DSSTox Substance ID:DTXSID40370294
Wikidata:Q72454843
Mol file:39745-40-9.mol

Synonyms:3-Amino-2-chloro-6-picoline;39745-40-9;2-chloro-6-methylpyridin-3-amine;3-Amino-2-chloro-6-methylpyridine;5-Amino-6-chloro-2-picoline;2-CHLORO-3-AMINO-6-METHYLPYRIDINE;2-Chloro-6-methyl-pyridin-3-ylamine;MFCD03095213;3-PYRIDINAMINE, 2-CHLORO-6-METHYL-;SCHEMBL190651;2-chloro-3-amino-6-picoline;DTXSID40370294;SUMSBUDMYMYTLL-UHFFFAOYSA-N;BCP22100;2-chloro-6-methyl-3-pyridinylamine;3-amino-2-chloro-6- methylpyridine;BBL104001;GEO-00103;STL557812;AKOS005257125;AB13580;AC-24830;SY021486;TS-01855;3-amino-2-chloro-6-picoline, AldrichCPR;5-AMINO-6-CHLORO-2-METHYLPYRIDINE;A6636;AM20061778;CS-0007527;FT-0639574;EN300-102383;W-200343;3-Amino-2-Chloro-6-methylpyridine

Suppliers and Price of 3-Amino-2-chloro-6-picoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-Amino-2-chloro-6-picoline
1g
$ 75.00

SynQuest Laboratories
3-Amino-2-chloro-6-methylpyridine
1 g
$ 64.00

SynQuest Laboratories
3-Amino-2-chloro-6-methylpyridine
250 mg
$ 35.00

Matrix Scientific
3-Amino-2-chloro-6-methylpyridine 98%
1g
$ 10.00

Matrix Scientific
3-Amino-2-chloro-6-methylpyridine 98%
5g
$ 37.00

Crysdot
3-Amino-2-chloro-6-picoline 98%
100g
$ 495.00

Chemenu
3-Amino-2-chloro-6-picoline 98%
100g
$ 468.00

Chemenu
3-Amino-2-chloro-6-picoline 98%
25g
$ 163.00

Biosynth Carbosynth
3-Amino-2-chloro-6-picoline
10 g
$ 231.00

Biosynth Carbosynth
3-Amino-2-chloro-6-picoline
5 g
$ 136.50

Total 65 raw suppliers

Chemical Property of 3-Amino-2-chloro-6-picoline

Chemical Property:

Appearance/Colour:Light yellow cryst.
Vapor Pressure:0.011mmHg at 25°C
Melting Point:88-91 °C
Refractive Index:1.592
Boiling Point:262.3 °C at 760 mmHg
PKA:3.38±0.10(Predicted)
Flash Point:112.5 °C
PSA：38.91000
Density:1.26 g/cm³
LogP:2.20680
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:142.0297759
Heavy Atom Count:9
Complexity:97.1

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-2-chloro-6-picoline ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 36/37/38-20/21/22-41-37/38-22
Safety Statements: 36/37/39-26-39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC(=C(C=C1)N)Cl

Technology Process of 3-Amino-2-chloro-6-picoline

There total 8 articles about 3-Amino-2-chloro-6-picoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.5%

: 56057-19-3
2-chloro-6-methyl-3-nitropyridine

: 39745-40-9
2-chloro-6-methyl-3-aminopyridine

Guidance literature:: With hydrazine hydrate; nickel; In ethanol; 70 deg C, 10 min; room temperature, 0.5 h;
DOI:10.1007/BF01169229

Reference yield:

: 38116-61-9
2-hydroxy-6-methylnicotinic acid

: 39745-40-9
2-chloro-6-methyl-3-aminopyridine

Guidance literature:: Multi-step reaction with 3 steps

1: POCl₃, PCl₅ / 3 h / Heating

2: conc. ammonium hydroxide / CHCl₃ / 0 °C

3: 1.4 g / Br₂, aq. NaOH / 1.) 0 deg C, 15 min, 2.) 75 deg C, 45 min

With ammonium hydroxide; sodium hydroxide; phosphorus pentachloride; bromine; trichlorophosphate; In chloroform;
DOI:10.1021/jm00114a007

Reference yield:

: 39853-81-1
2-chloro-6-methyl-nicotinic acid chloride

: 39745-40-9
2-chloro-6-methyl-3-aminopyridine

Guidance literature:: Multi-step reaction with 2 steps

1: conc. ammonium hydroxide / CHCl₃ / 0 °C

2: 1.4 g / Br₂, aq. NaOH / 1.) 0 deg C, 15 min, 2.) 75 deg C, 45 min

With ammonium hydroxide; sodium hydroxide; bromine; In chloroform;
DOI:10.1021/jm00114a007