Imidazo[1,2-c]quinazoline, 2,3-diphenyl-

Base Information

• Chemical Name: Imidazo[1,2-c]quinazoline, 2,3-diphenyl-
• CAS No.: 52747-80-5
• Molecular Formula: C22H15N3
• Molecular Weight: 321.381
• Mol file: 52747-80-5.mol

Synonyms:

Chemical Property of Imidazo[1,2-c]quinazoline, 2,3-diphenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[1,2-c]quinazoline, 2,3-diphenyl-

There total 12 articles about Imidazo[1,2-c]quinazoline, 2,3-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N,N-dimethyl acetamide (127-19-5,116057-81-9) + 2-(2-bromophenyl)-4,5-diphenyl-1H-imidazole (1740-25-6) → 2,3-diphenylimidazo[1,2-c]quinazoline (52747-80-5)

Guidance literature:

With tert.-butylhydroperoxide; copper(l) iodide; sodium azide; toluene-4-sulfonic acid; at 130 ℃; for 10h; Reagent/catalyst; Catalytic behavior;

DOI:10.1002/ejoc.201601329

Reference yield: 71.0%

N-(2-(4,5-diphenyl-1H-imidazol-2-yl)phenyl)formamide → 2,3-diphenylimidazo[1,2-c]quinazoline (52747-80-5)

Guidance literature:

With copper(l) iodide; sodium methylate; In N,N-dimethyl-formamide; at 150 ℃; for 12h;

DOI:10.1039/c5ob02469b

Reference yield: 68.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(2-nitrophenyl)-4,5-diphenylimidazole (29864-19-5) → 2,3-diphenylimidazo[1,2-c]quinazoline (52747-80-5)

Guidance literature:

With titanium tetrachloride; zinc; In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1055/s-2004-822893

upstream raw materials:

2-(4,5-diphenyl-1H-imidazol-2-yl)phenylamine

orthoformic acid triethyl ester

formaldehyd

2-(2-nitrophenyl)-4,5-diphenylimidazole

Refernces

• 1、 Shi, Daqing,Wang, Juxian,Shi, Chunling,Rong, Liangce,Zhuang, Qiya,Hu, Hongwen. "Synthesis of quinazolines and imidazo[1,2-c]quinazolines with the aid of a low-valent titanium reagent". . p. 1098 - 1100. Retrieved 2004.
• 2、 Shi, Daqing,Shi, Chunling,Wang, Juxian,Rong, Liangce,Zhuang, Qiya,Wang, Xiangshan. "An efficient synthesis of quinazoline derivatives with the aid of low-valent titanium reagent". . p. 173 - 183. Retrieved 2007/10/03.