1-Azabicyclo[2.2.2]octan-3-one, 2-methyl-

Base Information

• Chemical Name: 1-Azabicyclo[2.2.2]octan-3-one, 2-methyl-
• CAS No.: 5291-14-5
• Molecular Formula: C8H13NO
• Molecular Weight: 139.197
• Mol file: 5291-14-5.mol

Synonyms:

Chemical Property of 1-Azabicyclo[2.2.2]octan-3-one, 2-methyl-

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Azabicyclo[2.2.2]octan-3-one, 2-methyl-

There total 5 articles about 1-Azabicyclo[2.2.2]octan-3-one, 2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-methylenequinuclidin-3-one (5291-26-9) → 2-Methyl-3-oxoquinuclidine (5291-14-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; for 0.75h; under 51.7162 Torr;

Reference yield: 58.0%

2-methylene-3-quinuclidinone hydrochloride (5832-54-2) → 2-Methyl-3-oxoquinuclidine (5291-14-5)

Guidance literature:

With hydrogen; potassium carbonate; platinum(IV) oxide; In methanol; for 1h; under 517.162 - 775.743 Torr;

Reference yield: 32.0%

3-Quinuclidinone (3731-38-2) + Dimethyldisulphide (624-92-0) → 2-Methyl-3-oxoquinuclidine (5291-14-5)

Guidance literature:

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/S0040-4020(00)00015-6

upstream raw materials:

3-Quinuclidinone

Dimethyldisulphide

2-methylene-3-quinuclidinone hydrochloride

2-methylenequinuclidin-3-one

Downstream raw materials:

2-Methylquinuclidine

2-methyl-1-azabicyclo[2.2.2]octan-3-one oxime

(2,4-dimethoxy-benzyl)-(2-methyl-1-aza-bicyclo[2.2.2]oct-3-yl)-amine

(3E/Z)-2-methyl-1-azabicyclo[2.2.2]octan-3-one oxime hydrochloride

Refernces

• 1、 -. "Glucosylceramide synthase inhibitors". Page/Page column 51. . Retrieved 2015/09/28.
• 2、 -. "1H-PYRAZOLE AND 1H-PYRROLE-AZABICYCLIC COMPOUNDS WITH ALFA-7 NACHR ACTIVITY". Page 67. . Retrieved 2010/02/06.