N,N-diethylpentanamide

Base Information

• Chemical Name: N,N-diethylpentanamide
• CAS No.: 922-13-4
• Molecular Formula: C9H19 N O
• Molecular Weight: 157.256
• Mol file: 922-13-4.mol

Synonyms:Valeramide,N,N-diethyl- (6CI,7CI,8CI); N,N-Diethylpentanamide; N,N-Diethylvaleramide; NSC142610; Valeric acid diethylamide

Chemical Property of N,N-diethylpentanamide

Chemical Property:

• Vapor Pressure: 0.113mmHg at 25°C
• Boiling Point: 220.4°Cat760mmHg
• Flash Point: 83°C
• PSA: 20.31000
• Density: 0.866g/cm³
• LogP: 2.04500

Purity/Quality:

99% ^*data from raw suppliers

N,N-DIETHYLPENTANAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-diethylpentanamide

There total 15 articles about N,N-diethylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

n-valeryl chloride (638-29-9) + diethylamine (109-89-7) → n-pentanoic acid diethylamide (922-13-4)

Guidance literature:

In dichloromethane; at -50 - 20 ℃;

DOI:10.1021/ja056076i

Reference yield: 72.0%

butyl magnesium bromide (693-04-9) + C17H37NOP(1+)*Cl(1-) → n-pentanoic acid diethylamide (922-13-4)

Guidance literature:

With bis(triphenylphosphine)nickel(II) chloride; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/S0040-4039(00)01783-4

Reference yield:

n-butyllithium (109-72-8,29786-93-4) + N,N-diethylcarbamyl chloride (88-10-8) → n-pentanoic acid diethylamide (922-13-4) + N,N,N',N'-tetraethylurea (1187-03-7)

Guidance literature:

n-butyllithium; With CuCN; In tetrahydrofuran; at -30 ℃; for 0.5h;

N,N-diethylcarbamyl chloride; In tetrahydrofuran; at -30 - 0 ℃; for 2h;

DOI:10.1021/ol0487130

upstream raw materials:

diethylamine

valeric acid

1-Diaethylamino-pent-1-in

2-Diethylaminotetrahydropyran

Downstream raw materials:

N-ethyl-pentanamide

N,N-diethylthiopentanamide

nonanone-5

valeric acid

Refernces

• 1、 Hama, Takuo,Culkin, Darcy A.,Hartwig, John F.. "Palladium-catalyzed intermolecular α-arylation of zinc amide enolates under mild conditions". . p. 4976 - 4985. Retrieved 2007/10/03.
• 2、 Lemoucheux,Rouden,Lasne. "Cross-coupling reactions of carbamoyl chlorides and Grignard reagents: A new rapid synthesis of tertiary amides". . p. 9997 - 10001. Retrieved 2007/10/03.