4-Isocyanatooxane

Base Information

• Chemical Name: 4-Isocyanatooxane
• CAS No.: 53035-92-0
• Molecular Formula: C6H9NO2
• Molecular Weight: 127.143
• Hs Code.: 2932999099
• Mol file: 53035-92-0.mol

Synonyms:4-ISOCYANATO-TETRAHYDRO-PYRAN;4-ISOCYANATOTETRAHYDRO-2H-PYRAN;4-tetrahydropyranyl-isocyanate;

Chemical Property of 4-Isocyanatooxane

Chemical Property:

• PSA: 38.66000
• LogP: 0.50120

Purity/Quality:

97% ^*data from raw suppliers

4-Isocyanatooxane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Isocyanatooxane

There total 3 articles about 4-Isocyanatooxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetrahydro-2H-pyran-4-carboxylic acid (5337-03-1) → 4-isocyanatotetrahydro-2H-pyran (53035-92-0)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In toluene; at 20 - 80 ℃;

DOI:10.1021/jm980576n

Reference yield:

4-aminotetrahydropyran (38041-19-9) + bis(trichloromethyl) carbonate (32315-10-9) → 4-isocyanatotetrahydro-2H-pyran (53035-92-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

→ 4-isocyanatotetrahydro-2H-pyran (53035-92-0)

Guidance literature:

upstream raw materials:

tetrahydro-2H-pyran-4-carboxylic acid

4-aminotetrahydropyran

bis(trichloromethyl) carbonate

Downstream raw materials:

4,6-dichloro-3-[2-(4-{[3-(tetrahydro-pyran-4-yl)-ureido]-methyl}-phenylcarbamoyl)-vinyl]-1H-indole-2-carboxylic acid ethyl ester

1,1-dimethylethyl-4-({[4-(4-morpholinyl)phenyl][(tetrahydro-2H-pyran-4-ylamino)carbonyl]amino}methyl)-1-piperidinecarboxylate

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