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38041-19-9

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38041-19-9 Usage

Description

4-Aminotetrahydropyran contains the tetrahydropyran ring, which is the most frequently reported three-dimensional ring system in marketed drugs, and is second only to the phenyl ring when two-dimensional rings are included. It can be used as reactant/reagent in synthesis of aminothiazole compounds for use in treatment of cancer. Its scaffold is very useful in the drug discovery for cancer treatment.

Application

4-Aminotetrahydropyran can be used as reactant/reagent in synthesis of aminothiazole compounds for use in treatment of cancer.

Check Digit Verification of cas no

The CAS Registry Mumber 38041-19-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,0,4 and 1 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 38041-19:
(7*3)+(6*8)+(5*0)+(4*4)+(3*1)+(2*1)+(1*9)=99
99 % 10 = 9
So 38041-19-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H11NO/c6-5-1-3-7-4-2-5/h5H,1-4,6H2/p+1

38041-19-9 Well-known Company Product Price

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  • Aldrich

  • (711357)  4-Aminotetrahydropyran  97%

  • 38041-19-9

  • 711357-1G

  • 1,385.28CNY

  • Detail

38041-19-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Aminotetrahydropyran

1.2 Other means of identification

Product number -
Other names 4-Aminotetrahydro-2H-pyran

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:38041-19-9 SDS

38041-19-9Relevant articles and documents

Preparation method of important intermediate 4-aminotetrahydropyran

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Paragraph 0019-0025; 0026-0032; 0033-0039; 0040-0053; 0055, (2018/12/14)

The invention discloses a preparation method of an important intermediate 4-aminotetrahydropyran. The method comprises the following steps that tetrahydro-4-pyranol is dissolved in polyethylene glycol-200, a prepared Cu-Mo/TS-1 composite is added, a mixture is heated to 60-80 DEG C, under a stirring condition, ammonium hydroxide is added into the mixture dropwise, after dropping is completed, heat-preservation stirring reaction is carried out for 5-6 h, and filtering, extraction and recrystallization are conducted to prepare the 4-aminotetrahydropyran. The preparation method is simple to operate, conditions are mild, by-products are few, the product purity is high, and the product yield is high.

Heterogeneous Catalytic Reductive Amination of Carbonyl Compounds with Ni-Al Alloy in Water as Solvent and Hydrogen Source

Sch?fer, Christian,Ni?anci, Bilal,Bere, Matthew P.,Da?tan, Arif,T?r?k, Béla

, p. 3127 - 3133 (2016/09/09)

The heterogeneous catalytic reductive amination of carbonyl compounds has been achieved by reactions of ammonium hydroxide and various amines with ketones and aldehydes. The process is based on the application of Raney type Ni-Al alloy in an aqueous medium. The reaction of the carbonyl compounds with the amine provided the corresponding Schiff bases that immediately underwent a reduction to provide primary and secondary amines as products. The controlled reaction of the Al content of the alloy with the solvent water generates hydrogen, and the in situ formed Raney Ni serves as a hydrogenation catalyst. The method is a simple and efficient way of preparing a broad variety of primary and secondary amines.

IMIDAZO [1, 2 - B] PYRIDAZINE - BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF

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Page/Page column 29, (2013/09/26)

Imidazo[1,2-b]pyridazine-based compounds of the formula (I): are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

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