(2-Anilinophenyl)methanol

Base Information

• Chemical Name: (2-Anilinophenyl)methanol
• CAS No.: 53044-24-9
• Molecular Formula: C13H13NO
• Molecular Weight: 199.252
• Hs Code.: 2922199090
• European Community (EC) Number: 873-255-6
• DSSTox Substance ID: DTXSID70506766
• Nikkaji Number: J129.092D
• Wikidata: Q82362674
• Mol file: 53044-24-9.mol

Synonyms:(2-Anilinophenyl)methanol;53044-24-9;SCHEMBL1520973;DTXSID70506766;[2-(PHENYLAMINO)PHENYL]METHANOL;EN300-7352826

Chemical Property of (2-Anilinophenyl)methanol

Chemical Property:

• PSA: 32.26000
• LogP: 2.99550
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 199.099714038
• Heavy Atom Count: 15
• Complexity: 177

Purity/Quality:

99% ^*data from raw suppliers

(2-Anilinophenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NC2=CC=CC=C2CO

Technology Process of (2-Anilinophenyl)methanol

There total 7 articles about (2-Anilinophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl 2-(phenylamino)benzoate (23868-11-3) → N-Phenyl-o-(hydroxymethyl)aniline (53044-24-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 2.5h; Cooling with ice;

DOI:10.1071/CH12548

Reference yield: 75.0%

2-(hydroxymethyl)phenylboronic acid (87199-14-2) + Nitrosobenzene (586-96-9) → N-Phenyl-o-(hydroxymethyl)aniline (53044-24-9)

Guidance literature:

With triethyl phosphite; In toluene; at 20 ℃; for 0.75h;

DOI:10.1021/acs.orglett.8b00473

Reference yield: 74.0%

N-phenyl isatoic anhydride (20877-86-5) → N-Phenyl-o-(hydroxymethyl)aniline (53044-24-9)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; Ambient temperature;

DOI:10.1002/jhet.5570230145

upstream raw materials:

N-phenyl isatoic anhydride

ethyl 2-(phenylamino)benzoate

2-(phenylamino)benzoic acid

2-Iodobenzoic acid

Downstream raw materials:

1-phenyl-1H-benzo[d][1,3]oxazin-2(4H)-one

bromure d'o-(N-phenylamino)benzyltriphenylphosphonium

acridine

acridine