Technology Process of 1H-Indene-2-carboxylic acid, 2,3-dihydro-1-oxo-2-(phenylmethyl)-,
methyl ester, (2R)-
There total 10 articles about 1H-Indene-2-carboxylic acid, 2,3-dihydro-1-oxo-2-(phenylmethyl)-,
methyl ester, (2R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: KOH / ethanol / Heating
2: SOCl2 / Heating
3: SnCl4 / benzene / Heating
4: NaBH4 / ethanol / Ambient temperature
5: (i) KOH, EtOH, (ii) (racemate resolution using cinchonidine), (iii) /BRN= 102415/
6: DCC, Py, CF3CO2H / benzene; dimethylsulfoxide / Ambient temperature
With
pyridine; potassium hydroxide; sodium tetrahydroborate; thionyl chloride; tin(IV) chloride; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
ethanol; dimethyl sulfoxide; benzene;
DOI:10.1007/BF00912610
- Guidance literature:
-
Multi-step reaction with 5 steps
1: SOCl2 / Heating
2: SnCl4 / benzene / Heating
3: NaBH4 / ethanol / Ambient temperature
4: (i) KOH, EtOH, (ii) (racemate resolution using cinchonidine), (iii) /BRN= 102415/
5: DCC, Py, CF3CO2H / benzene; dimethylsulfoxide / Ambient temperature
With
pyridine; sodium tetrahydroborate; thionyl chloride; tin(IV) chloride; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
ethanol; dimethyl sulfoxide; benzene;
DOI:10.1007/BF00912610
- Guidance literature:
-
With
C56H62N4O4(2+)*2Cl(1-); potassium hydroxide;
In
chloroform; toluene;
at 25 ℃;
for 1h;
optical yield given as %ee;
enantioselective reaction;
DOI:10.3998/ark.5550190.0012.710
