3-{[2-(2-Methoxyethoxy)ethoxy]methyl}-3-methyloxetane

Base Information

• Chemical Name: 3-{[2-(2-Methoxyethoxy)ethoxy]methyl}-3-methyloxetane
• CAS No.: 531521-23-0
• Molecular Formula: C10H20O4
• Molecular Weight: 204.266
• DSSTox Substance ID: DTXSID30461928
• Nikkaji Number: J1.920.710B
• Wikidata: Q82286384
• Mol file: 531521-23-0.mol

Synonyms:531521-23-0;3-{[2-(2-METHOXYETHOXY)ETHOXY]METHYL}-3-METHYLOXETANE;3-[2-(2-methoxyethoxy)ethoxymethyl]-3-methyloxetane;Oxetane, 3-[[2-(2-methoxyethoxy)ethoxy]methyl]-3-methyl-;3-{[2-(2-Methoxyethoxy)ethoxy]methyl-3-methyloxetane;3-((2-(2-Methoxyethoxy)ethoxy)methyl)-3-methyloxetane;MFCD30531305;3-([2-(2-Methoxyethoxy)ethoxy]methyl)-3-methyloxetane;3-[[2-(2-Methoxyethoxy)ethoxy]methyl]-3-methyloxetane;SCHEMBL2623189;DTXSID30461928;AKOS030630877;PB42988;AS-53476;SY099385;CS-0051558;P16553

Chemical Property of 3-{[2-(2-Methoxyethoxy)ethoxy]methyl}-3-methyloxetane

Chemical Property:

• XLogP3: 0.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 204.13615911
• Heavy Atom Count: 14
• Complexity: 145

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(COC1)COCCOCCOC

Technology Process of 3-{[2-(2-Methoxyethoxy)ethoxy]methyl}-3-methyloxetane

There total 3 articles about 3-{[2-(2-Methoxyethoxy)ethoxy]methyl}-3-methyloxetane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-bromomethyl-3-methyloxetane (78385-26-9) + 2-(2-methoxyethoxy)ethyl alcohol (111-77-3,95507-80-5) → 3-[(2-(2-methoxyethoxy)ethoxy)methyl]-3-methyloxetane (531521-23-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 65 ℃; for 4h; Inert atmosphere;

DOI:10.1246/bcsj.20100155

Reference yield: 70.0%

2-(2-methoxyethoxy)ethyl alcohol (111-77-3,95507-80-5) + (3-methyloxetan-3-yl)methyl 4-methylbenzenesulfonate (99314-44-0) → 3-[(2-(2-methoxyethoxy)ethoxy)methyl]-3-methyloxetane (531521-23-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 48h;

Reference yield:

3-hydroxymethyl-3-methyloxethane (3143-02-0) → 3-[(2-(2-methoxyethoxy)ethoxy)methyl]-3-methyloxetane (531521-23-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 65 °C / Inert atmosphere

2: sodium bromide / acetone / 40 h / Reflux; Inert atmosphere

3: sodium hydride / tetrahydrofuran; mineral oil / 4 h / 65 °C / Inert atmosphere

With sodium hydride; sodium bromide; In tetrahydrofuran; acetone; mineral oil;

DOI:10.1246/bcsj.20100155

upstream raw materials:

3-bromomethyl-3-methyloxetane

2-(2-methoxyethoxy)ethyl alcohol

3-hydroxymethyl-3-methyloxethane

(3-methyloxetan-3-yl)methyl 4-methylbenzenesulfonate