[2-(11,17-dihydroxy-9-methoxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14, 15,16-decahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] acetate

Base Information

• Chemical Name: [2-(11,17-dihydroxy-9-methoxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14, 15,16-decahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] acetate
• CAS No.: 6635-85-4
• Molecular Formula: C₂₄H₃₄O₇
• Molecular Weight: 434.53
• Mol file: 6635-85-4.mol

Synonyms:Corticosterone,17-hydroxy-9-methoxy-, 21-acetate (6CI); NSC 52436

Chemical Property of [2-(11,17-dihydroxy-9-methoxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14, 15,16-decahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] acetate

Chemical Property:

• Vapor Pressure: 2.91E-16mmHg at 25°C
• Boiling Point: 587.7°C at 760 mmHg
• Flash Point: 196.5°C
• PSA: 110.13000
• Density: 1.27g/cm³
• LogP: 2.12140

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [2-(11,17-dihydroxy-9-methoxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14, 15,16-decahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] acetate

There total 6 articles about [2-(11,17-dihydroxy-9-methoxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14, 15,16-decahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

21-acetoxy-9,11β-epoxy-17-hydroxy-9β-pregn-4-ene-3,20-dione (4383-30-6,96843-90-2) → 21-acetoxy-11β,17-dihydroxy-9-methoxy-pregn-4-ene-3,20-dione (6635-85-4)

Guidance literature:

With perchloric acid; Behandeln des Reaktionsprodukts mit Acetanhydrid und Pyridin;

DOI:10.1021/ja01562a030

Reference yield:

Epicortisol (566-35-8) → 21-acetoxy-11β,17-dihydroxy-9-methoxy-pregn-4-ene-3,20-dione (6635-85-4)

Guidance literature:

Multi-step reaction with 5 steps

1: dann mit Methansulfonylchlorid

2: sodium acetate; acetic acid

3: HClO₄; aqueous dioxane

4: dioxane; potassium acetate; ethanol

5: methanol.HClO₄ / Behandeln des Reaktionsprodukts mit Acetanhydrid und Pyridin

With 1,4-dioxane; perchloric acid; ethanol; potassium acetate; sodium acetate; acetic acid;

DOI:10.1021/ja01562a030

Reference yield:

anecortave (7753-60-8) → 21-acetoxy-11β,17-dihydroxy-9-methoxy-pregn-4-ene-3,20-dione (6635-85-4)

Guidance literature:

Multi-step reaction with 3 steps

1: HClO₄; aqueous dioxane

2: dioxane; potassium acetate; ethanol

3: methanol.HClO₄ / Behandeln des Reaktionsprodukts mit Acetanhydrid und Pyridin

With 1,4-dioxane; perchloric acid; ethanol; potassium acetate;

DOI:10.1021/ja01562a030

upstream raw materials:

21-acetoxy-9,11β-epoxy-17-hydroxy-9β-pregn-4-ene-3,20-dione

Epicortisol

anecortave

21-acetoxy-9-bromo-11β,17-dihydroxy-pregn-4-ene-3,20-dione