566-35-8

Basic information

• Product Name: 11-ALPHA-HYDROCORTISONE
• Synonyms: Pregn-4-ene-11,17,21-triol-3,20-dione;EPI COMPOUND ''F'';EPI COMPOUND 'F';11-EPICORTISOL;11-EPIHYDROCORTISONE;11-ALPHA-HYDROCORTISONE;4-PREGNEN-11-ALPHA, 17,21-TRIOL-3,20-DIONE;4-PREGNEN-11ALPHA,17ALPHA,21-TETROL-3,20-DIONE
• CAS NO: 566-35-8
• Molecular Formula: C₂₁H₃₀O₅
• Molecular Weight: 362.46
• Mol File: 566-35-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 217-219 °C
• Boiling Point: 566.4°Cat760mmHg
• Flash Point: 310.4°C
• Appearance: /
• Density: 1.28g/cm³
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
• PKA: 12.47±0.70(Predicted)
• CAS DataBase Reference: 11-ALPHA-HYDROCORTISONE(CAS DataBase Reference)
• NIST Chemistry Reference: 11-ALPHA-HYDROCORTISONE(566-35-8)
• EPA Substance Registry System: 11-ALPHA-HYDROCORTISONE(566-35-8)

Safety Data

• Hazardous Substances Data: 566-35-8(Hazardous Substances Data)

Usage

Description

11-ALPHA-HYDROCORTISONE, also known as 11-Epihydrocortisone, is an isomer of Hydrocortisone (H714615). It is a glucocorticoid that plays a crucial role in various physiological processes, including increasing blood sugar levels through gluconeogenesis, suppressing the immune system, and aiding in the metabolism of fat, protein, and carbohydrates.

Uses

Used in Pharmaceutical Industry:
11-ALPHA-HYDROCORTISONE is used as a glucocorticoid for its ability to increase blood sugar through gluconeogenesis, suppress the immune system, and aid in the metabolism of fat, protein, and carbohydrates. This makes it a valuable compound in the development of medications for various health conditions.
Used in Endocrinology:
In the field of endocrinology, 11-ALPHA-HYDROCORTISONE is used as a therapeutic agent to manage conditions related to hormonal imbalances, such as adrenal insufficiency and other disorders affecting the adrenal glands.
Used in Immunology:
11-ALPHA-HYDROCORTISONE is used as an immunosuppressive agent to help control autoimmune diseases and reduce inflammation. Its ability to suppress the immune system makes it a useful tool in managing conditions like rheumatoid arthritis, lupus, and other autoimmune disorders.
Used in Metabolic Disorders:
11-ALPHA-HYDROCORTISONE is used as a treatment for metabolic disorders that involve issues with fat, protein, and carbohydrate metabolism. Its role in aiding these metabolic processes makes it a potential therapeutic option for conditions like diabetes and metabolic syndrome.

Upstream product

• 152-58-9 Cortexolone 
• 50-23-7 HYDROCORTISONE 
• 152-58-9 C₂₁H₃₀O₄ 

Downstream Products

• 111669-30-8 11α,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-tosylate 
• 1250-97-1 11α,17α-dihydroxyprogesterone-21-acetate 
• 76338-54-0 3,3;20,20-bis-ethanediyldioxy-pregn-5-ene-11β,17,21-triol 
• 101524-47-4 3,3;20,20-bis-ethanediyldioxy-17,21-dihydroxy-pregn-5-en-11-one 
• 50-23-7 HYDROCORTISONE 
• 4383-30-6 21-acetoxy-9,11α-epoxy-17-hydroxy-pregn-4-ene-3,20-dione 
• 4383-30-6 21-acetoxy-9,11β-epoxy-17-hydroxy-9β-pregn-4-ene-3,20-dione 
• 10072-97-6 9,11β-epoxy-17,21-dihydroxy-9β-pregn-4-ene-3,20-dione 
• 114909-20-5 17,21-dihydroxy-11α-(toluene-4-sulfonyloxy)-pregn-4-ene-3,20-dione 
• 6635-85-4 21-acetoxy-11β,17-dihydroxy-9-methoxy-pregn-4-ene-3,20-dione 
• 50733-54-5 21-acetoxy-9-bromo-11β,17-dihydroxy-pregn-4-ene-3,20-dione 
• 29042-01-1 21-acetoxy-9-chloro-11β,17-dihydroxy-pregn-4-ene-3,20-dione 
• 79-60-7 9α-fluorocortisone 
• 357-09-5 9α-Fluor-11β-hydroxy-3,17-dioxo-androsten-4 

Relevant articles and documents

Dehalogenation methodof 9-halogenated steroid compound and application

The invention provides a dehalogenation method of a 9-halogenated steroid compound and application, and relates to the technical field of chemical synthesis. The dehalogenation method of the 9-halogenated steroid compound comprises the following steps: reacting a compound I with a hydrogen donor and an azo radical initiator to obtain a 9-dehalogenated product compound II of the 9-halogenated steroid compound. According to the dehalogenation method of the 9-halogenated steroid compound, a hydrogen donor adopts one or a combination of more of hypophosphorous acid and hypophosphite, formic acid and formate, organic silicon hydride, hydrazine compounds or cyclohexene, and an initiator adopts an azo free radical initiator. Reagents such as chromium, divalent chromium salt, trivalent chromium salt or tributyltin hydride which are high in toxicity and cause serious pollution to the environment are not used in the reaction, the method is green and environmentally friendly, the synthesis process is simple, convenient and easy to implement, and the production applicability is improved.

MICROBIOLOGICAL HYDROXYLATION OF STEROIDS. IV. INFLUENCE OF THERMAL TREATMENT ON THE ENZYME ACTIVITY OF HYDROXYLATING CULTURES

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