9-Bromo-11,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate

Base Information

• Chemical Name: 9-Bromo-11,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate
• CAS No.: 50733-54-5
• Molecular Formula: C23H31BrO6
• Molecular Weight: 483.4
• Mol file: 50733-54-5.mol

Synonyms:9-Bromo-11,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate;9-Bromopregn-4-ene-11,17,21-triol-3,20-dione 21-acetate

Chemical Property of 9-Bromo-11,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate

Chemical Property:

• PSA: 100.90000
• LogP: 2.86990

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-Bromo-11,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate

There total 7 articles about 9-Bromo-11,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

anecortave (7753-60-8) → 21-acetoxy-9-bromo-11β,17-dihydroxy-pregn-4-ene-3,20-dione (50733-54-5)

Guidance literature:

With perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; In methanol; at 25 - 30 ℃; for 5h; Solvent; Reagent/catalyst; Inert atmosphere;

Reference yield:

Epicortisol (566-35-8) → 21-acetoxy-9-bromo-11β,17-dihydroxy-pregn-4-ene-3,20-dione (50733-54-5)

Guidance literature:

Multi-step reaction with 3 steps

1: dann mit Methansulfonylchlorid

2: sodium acetate; acetic acid

3: HClO₄; aqueous dioxane

With 1,4-dioxane; perchloric acid; sodium acetate; acetic acid;

DOI:10.1021/ja01562a030

Reference yield:

21-acetoxy-17-hydroxy-11α-methanesulfonyloxy-pregn-4-ene-3,20-dione (113862-93-4) → 21-acetoxy-9-bromo-11β,17-dihydroxy-pregn-4-ene-3,20-dione (50733-54-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate; acetic acid

2: HClO₄; aqueous dioxane

With 1,4-dioxane; perchloric acid; sodium acetate; acetic acid;

DOI:10.1021/ja01562a030

upstream raw materials:

anecortave

N-bromoacetamide

Epicortisol

21-acetoxy-17-hydroxy-11α-methanesulfonyloxy-pregn-4-ene-3,20-dione

Downstream raw materials:

9,11β-epoxy-17,21-dihydroxy-9β-pregn-4-ene-3,20-dione

21-acetoxy-9,11β-epoxy-17-hydroxy-9β-pregn-4-ene-3,20-dione

21-acetoxy-11β,17-dihydroxy-pregna-4,8-diene-3,20-dione

Fludrocortisone