N-cyclopentylbenzamide

Base Information

• Chemical Name: N-cyclopentylbenzamide
• CAS No.: 53226-42-9
• Molecular Formula: C12H15NO
• Molecular Weight: 189.257
• Mol file: 53226-42-9.mol

Synonyms:

Chemical Property of N-cyclopentylbenzamide

Chemical Property:

• PSA: 29.10000
• LogP: 2.74990

Purity/Quality:

99% ^*data from raw suppliers

N-CYCLOPENTYLBENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-cyclopentylbenzamide

There total 47 articles about N-cyclopentylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzoyl chloride (98-88-4) + Cyclopentamine (1003-03-8) → N-cyclopentylbenzamide (53226-42-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 14h; Inert atmosphere;

DOI:10.1055/s-0037-1610411

Reference yield: 95.0%

tert-Butyl peroxybenzoate (614-45-9) + Cyclopentamine (1003-03-8) → N-cyclopentylbenzamide (53226-42-9)

Guidance literature:

In neat (no solvent); at 20 ℃; for 3h; chemoselective reaction;

DOI:10.1055/s-0034-1380811

Reference yield: 93.0%

Cyclopentamine (1003-03-8) + benzyl alcohol (100-51-6,185532-71-2) → N-cyclopentylbenzamide (53226-42-9)

Guidance literature:

With 1-methyl-1H-imidazole; 4,4'-Dimethoxy-2,2'-bipyridin; 9-azabicyclo<3.3.1>nonane-N-oxyl; oxygen; copper(l) chloride; In tetrahydrofuran; at 20 ℃; for 0.5h; under 760.051 Torr; Molecular sieve;

DOI:10.1021/jacs.6b03931

upstream raw materials:

benzoyl chloride

Cyclopentamine

Cyclopentanol

benzonitrile

Downstream raw materials:

N-Cyclopentyl-N-(pyridine-2-carbonyl)-benzamide

N-Cyclopentyl-N-(4-pyrrolidin-1-yl-pyridine-2-carbonyl)-benzamide

N-Cyclopentyl-N-(4-morpholin-4-yl-pyridine-2-carbonyl)-benzamide

benzonitrile