2'-Chloro-4'-methylacetanilide

Base Information

• Chemical Name: 2'-Chloro-4'-methylacetanilide
• CAS No.: 18931-78-7
• Molecular Formula: C9H10 Cl N O
• Molecular Weight: 183.637
• Hs Code.: 2924299090
• European Community (EC) Number: 606-169-2
• NSC Number: 159256
• DSSTox Substance ID: DTXSID00172337
• Nikkaji Number: J275.422C
• Mol file: 18931-78-7.mol

Synonyms:p-Acetotoluidide,2'-chloro- (6CI,8CI); 2'-Chloro-4'-acetotoluidide;2'-Chloro-4'-methylacetanilide; 2'-Chloro-p-acetotoluidide;4-Acetamido-3-chlorotoluene; N-(2-Chloro-4-methylphenyl)acetamide; NSC 159256

Chemical Property of 2'-Chloro-4'-methylacetanilide

Chemical Property:

• Boiling Point: 331.7°Cat760mmHg
• Flash Point: 154.4°C
• PSA: 29.10000
• Density: 1.218g/cm³
• LogP: 2.67980
• Storage Temp.: 2-8°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 183.0450916
• Heavy Atom Count: 12
• Complexity: 172

Purity/Quality:

99% ^*data from raw suppliers

N-(2-Chloro-4-methylphenyl)acetamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)NC(=O)C)Cl

Technology Process of 2'-Chloro-4'-methylacetanilide

There total 19 articles about 2'-Chloro-4'-methylacetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

acetic anhydride (108-24-7) + 2-chloro-4-methyl-benzenamine (615-65-6) → N-(2-chloro-4-methylphenyl)acetamide (18931-78-7)

Guidance literature:

for 0.666667h;

DOI:10.3891/acta.chem.scand.52-0549

Reference yield: 93.0%

4-Methylacetanilide (103-89-9) → N-(2-chloro-4-methylphenyl)acetamide (18931-78-7)

Guidance literature:

With copper diacetate; palladium diacetate; copper dichloride; at 120 ℃; for 2h; neat (no solvent);

DOI:10.1039/c003074k

Reference yield: 88.0%

4-Methylacetanilide (103-89-9) → N-(2-chloro-4-methylphenyl)acetamide (18931-78-7) + 2,5-dichloro-4-methylacetanilide

Guidance literature:

With hydrogenchloride; sodium chlorate; In water; acetic acid; at 20 ℃; for 1h;

DOI:10.5012/bkcs.2011.32.2.472

upstream raw materials:

N-chloro-succinimide

4-Methylacetanilide

chloroform

N-chloro-N-(4-methylphenyl)acetamide

Downstream raw materials:

2-chloro-4-methyl-6-nitroaniline

acetic acid-(2-chloro-4-methyl-6-nitro-anilide)

4-acetamido-3-chlorobenzoic acid

acetic acid-(2,6-dichloro-4-methyl-anilide)