4-Cyanobutanamide

Base Information

• Chemical Name: 4-Cyanobutanamide
• CAS No.: 53897-27-1
• Molecular Formula: C5H8N2O
• Molecular Weight: 112.131
• Hs Code.: 2926909090
• Mol file: 53897-27-1.mol

Synonyms:4-cyano-butyric acid amide;4-Cyanobutyramide;Butanamide,4-cyano;4-Cyan-buttersaeure-amid;

Chemical Property of 4-Cyanobutanamide

Chemical Property:

• Melting Point: 68-69 °C
• Boiling Point: 150-162 °C(Press: 0.5 Torr)
• PKA: 16.28±0.40(Predicted)
• PSA: 67.87000
• Density: 1.065±0.06 g/cm3(Predicted)
• LogP: 1.31528

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Cyanobutanamide

There total 6 articles about 4-Cyanobutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

Glutaronitrile (544-13-8) → 4-cyanobutanamide (53897-27-1) + pentanediamide (3424-60-0)

Guidance literature:

With sodium hydroxide; tricyclohexylphosphine; {Rh(OMe)(cod)}2; In isopropyl alcohol; at 25 ℃; for 48h;

DOI:10.1002/anie.200800366

Reference yield:

methyl 4-cyanobutanoate (41126-15-2) → 4-cyanobutanamide (53897-27-1)

Guidance literature:

With ammonium hydroxide; In water; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1055/s-0034-1378881

Reference yield:

4-cyanobutyric acid (39201-33-7) → 4-cyanobutanamide (53897-27-1)

Guidance literature:

With ammonia; In dichloromethane; at 25 ℃; for 1h;

upstream raw materials:

Glutaronitrile

methyl 4-cyanobutanoate

4-cyanobutyric acid

Downstream raw materials:

piperidin-2-one

Refernces

• 1、 -. "PYRIDAZINE DERIVATIVES AS RORC MODULATORS". Page/Page column 210; 211. . Retrieved 2018/05/24.
• 2、 Goto, Akihiro,Endo, Kohei,Saito, Susumu. "RhI-catalyzed hydration of organonitriles under ambient conditions". . p. 3607 - 3609. Retrieved 2008/12/23.