1-[4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]-2-(6-methylpyrazin-2-yl)ethanol

Base Information

• Chemical Name: 1-[4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]-2-(6-methylpyrazin-2-yl)ethanol
• CAS No.: 138488-57-0
• Molecular Formula: C₁₂H₁₅BrN₄OS
• Molecular Weight: 343.247
• Mol file: 138488-57-0.mol

Synonyms:Pyrazineethanol,a-[4-bromo-1-methyl-2-(methylthio)-1H-imidazol-5-yl]-6-methyl- (9CI)

Chemical Property of 1-[4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]-2-(6-methylpyrazin-2-yl)ethanol

Chemical Property:

• Vapor Pressure: 1.23E-10mmHg at 25°C
• Boiling Point: 495.5°C at 760 mmHg
• Flash Point: 253.5°C
• Density: 1.59g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]-2-(6-methylpyrazin-2-yl)ethanol

There total 3 articles about 1-[4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]-2-(6-methylpyrazin-2-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(6-methyl-2-pyrazinyl)-1-(1-methyl-2-(methylthio)-4-bromo-5-imidazolyl)ethan-1-one (138335-71-4) → 2-(6-methyl-2-pyrazinyl)-1-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)ethan-1-ol (138488-57-0)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; ethanol; 0 deg C to room temperature, overnight;

DOI:10.1021/jo00031a017

Reference yield:

2,6-dimethylpyrazine (108-50-9) → 2-(6-methyl-2-pyrazinyl)-1-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)ethan-1-ol (138488-57-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) LDA / 1) THF, hexanes, -78 deg C, 2) -19 to -15 deg C

2: 100 percent / NaBH₄ / ethanol; tetrahydrofuran / 0 deg C to room temperature, overnight

With sodium tetrahydroborate; lithium diisopropyl amide; In tetrahydrofuran; ethanol;

DOI:10.1021/jo00031a017

Reference yield:

Methyl 4-bromo-1-methyl-2-methylthio-5-imidazolecarboxylate (108905-63-1) → 2-(6-methyl-2-pyrazinyl)-1-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)ethan-1-ol (138488-57-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) LDA / 1) THF, hexanes, -78 deg C, 2) -19 to -15 deg C

2: 100 percent / NaBH₄ / ethanol; tetrahydrofuran / 0 deg C to room temperature, overnight

With sodium tetrahydroborate; lithium diisopropyl amide; In tetrahydrofuran; ethanol;

DOI:10.1021/jo00031a017

upstream raw materials:

2-(6-methyl-2-pyrazinyl)-1-(1-methyl-2-(methylthio)-4-bromo-5-imidazolyl)ethan-1-one

2,6-dimethylpyrazine

Methyl 4-bromo-1-methyl-2-methylthio-5-imidazolecarboxylate

Downstream raw materials:

(E)-2-(6-methyl-2-pyrazinyl)-1-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)ethene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 138488-57-0 1-[4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]-2-(6-methylpyrazin-2-yl)ethanol

Send

Send

Metric Ton KG G Pound L ML

Send

Send