2-((E)-2-(5-Bromo-3-methyl-2-methylthioimidazol-4-yl)ethenyl)-6-methylpyrazine

Base Information

Chemical Name:2-((E)-2-(5-Bromo-3-methyl-2-methylthioimidazol-4-yl)ethenyl)-6-methylpyrazine
CAS No.:138335-76-9
Molecular Formula:C12H13BrN4S
Molecular Weight:325.2274
Hs Code.:

Synonyms:2-((E)-2-(5-Bromo-3-methyl-2-methylthioimidazol-4-yl)ethenyl)-6-methylpyrazine;138335-76-9

Suppliers and Price of 2-((E)-2-(5-Bromo-3-methyl-2-methylthioimidazol-4-yl)ethenyl)-6-methylpyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-((E)-2-(5-Bromo-3-methyl-2-methylthioimidazol-4-yl)ethenyl)-6-methylpyrazine

Chemical Property:

Vapor Pressure:6.39E-09mmHg at 25°C
Boiling Point:467.7°Cat760mmHg
Flash Point:236.6°C
Density:1.49g/cm³
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:324.00443
Heavy Atom Count:18
Complexity:302

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CN=CC(=N1)C=CC2=C(N=C(N2C)SC)Br
Isomeric SMILES:CC1=CN=CC(=N1)/C=C/C2=C(N=C(N2C)SC)Br

Technology Process of 2-((E)-2-(5-Bromo-3-methyl-2-methylthioimidazol-4-yl)ethenyl)-6-methylpyrazine

There total 4 articles about 2-((E)-2-(5-Bromo-3-methyl-2-methylthioimidazol-4-yl)ethenyl)-6-methylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.3%

: 138488-57-0
2-(6-methyl-2-pyrazinyl)-1-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)ethan-1-ol

: 138335-76-9
(E)-2-(6-methyl-2-pyrazinyl)-1-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)ethene

Guidance literature:: With methanesulfonic acid; In toluene; for 0.333333h; Heating;
DOI:10.1021/jo00031a017

Reference yield:

: 108-50-9
2,6-dimethylpyrazine

: 138335-76-9
(E)-2-(6-methyl-2-pyrazinyl)-1-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)ethene

Guidance literature:: Multi-step reaction with 3 steps

1: 1) LDA / 1) THF, hexanes, -78 deg C, 2) -19 to -15 deg C

2: 100 percent / NaBH₄ / ethanol; tetrahydrofuran / 0 deg C to room temperature, overnight

3: 91.3 percent / methanesulfonic acid / toluene / 0.33 h / Heating

With sodium tetrahydroborate; methanesulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; toluene;
DOI:10.1021/jo00031a017

Reference yield:

: 108905-63-1
Methyl 4-bromo-1-methyl-2-methylthio-5-imidazolecarboxylate

: 138335-76-9
(E)-2-(6-methyl-2-pyrazinyl)-1-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)ethene

Guidance literature:: Multi-step reaction with 3 steps

1: 1) LDA / 1) THF, hexanes, -78 deg C, 2) -19 to -15 deg C

2: 100 percent / NaBH₄ / ethanol; tetrahydrofuran / 0 deg C to room temperature, overnight

3: 91.3 percent / methanesulfonic acid / toluene / 0.33 h / Heating

With sodium tetrahydroborate; methanesulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; toluene;
DOI:10.1021/jo00031a017