2,3-Dichloro-5-(chloromethyl)pyridine

Base Information

• Chemical Name: 2,3-Dichloro-5-(chloromethyl)pyridine
• CAS No.: 54127-31-0
• Molecular Formula: C6H4Cl3N
• Molecular Weight: 196.46200
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID70436438
• Wikidata: Q82251706
• Mol file: 54127-31-0.mol

Synonyms:2,3-dichloro-5-(chloromethyl)pyridine;54127-31-0;2,3-dichloro-5-(chloromethyl)-pyridine;Pyridine, 2,3-dichloro-5-(chloromethyl)-;SCHEMBL1141323;DTXSID70436438;XJCSQVBPRZIYPY-UHFFFAOYSA-N;2,3-dichloro-5-chloromethylpyridine;MFCD00125365;5-chloromethyl-2,3-dichloro-pyridine;2,3-Dichloro-5-chloromethyl-pyridine;AKOS015851119;CF-0755;FT-0683018;D97576;EN300-1983050;A870536

Chemical Property of 2,3-Dichloro-5-(chloromethyl)pyridine

Chemical Property:

• Boiling Point: 273.2±35.0 °C(Predicted)
• PKA: -1.51±0.10(Predicted)
• PSA: 12.89000
• Density: 1.463±0.06 g/cm3(Predicted)
• LogP: 3.12720
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 194.940932
• Heavy Atom Count: 10
• Complexity: 109

Purity/Quality:

98%min ^*data from raw suppliers

2,3-Dichloro-5-(chloromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1Cl)Cl)CCl
• Uses: 2,3-Dichloro-5-(chloromethyl)pyridine is an intermediate used in the synthesis of 5-Chloro Imidacloprid (C366910), which is an impurity of Imidacloprid (I274990), a neonicotinoid; the active ingredient in certain neuro-active insecticides.

Technology Process of 2,3-Dichloro-5-(chloromethyl)pyridine

There total 3 articles about 2,3-Dichloro-5-(chloromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5,6-dichloro-3-pyridinemethanol (54127-30-9) → 5-chloromethyl-2,3-dichloropyridine (54127-31-0)

Guidance literature:

With pyridine; thionyl chloride; at 0 - 20 ℃; for 2h;

Reference yield: 79.0%

2,3-dichloro-5-(trichloromethyl)pyridine (69045-83-6) → 5-chloromethyl-2,3-dichloropyridine (54127-31-0)

Guidance literature:

With acetic acid; zinc; In methanol; at -5 ℃; for 4h;

Reference yield:

→ 2-(5,6-dichloropyridin-3-yl)acetonitrile (54226-45-8) + 5-chloromethyl-2,3-dichloropyridine (54127-31-0)

Guidance literature:

upstream raw materials:

2,3-dichloro-5-(trichloromethyl)pyridine

5,6-dichloro-3-pyridinemethanol

Refernces

• 1、 -. "NOVEL INDAZOLE DERIVATIVE". Page/Page column 35. . Retrieved 2008/06/13.
• 2、 -. "2-(3-Amino-2-hydroxy-propoxy)-mono-and diazines". . . Retrieved 2008/06/13.