2,3-Dichloro-5-(trichloromethyl)pyridine

Base Information

• Chemical Name: 2,3-Dichloro-5-(trichloromethyl)pyridine
• CAS No.: 69045-83-6
• Molecular Formula: C6H2Cl5N
• Molecular Weight: 265.354
• Hs Code.: 2933399090
• UNII: H56Z8J98WV
• DSSTox Substance ID: DTXSID7029534
• Nikkaji Number: J1.581.752F
• Wikidata: Q27893568
• ChEMBL ID: CHEMBL3184088
• Mol file: 69045-83-6.mol

Synonyms:2,3-Dichloro-5-(trichloromethyl)pyridine;69045-83-6;2,3-dichloro-5-trichloromethylpyridine;Pyridine, 2,3-dichloro-5-(trichloromethyl)-;2,3-Dichloro-5-trichloromethyl-pyridine;H56Z8J98WV;DTXSID7029534;MFCD03701543;2,3-dichloro-5-(trichloromethyl) pyridine;UNII-H56Z8J98WV;DTXCID409534;SCHEMBL1747710;CHEMBL3184088;Tox21_301744;BBL103399;STL557209;AKOS005258558;SB38340;2,3-dichloro-5-trichloromethyl pyridine;5,6-dichloro-3-trichloromethyl pyridine;NCGC00255353-01;AC-23344;AS-46765;CAS-69045-83-6;A9152;FT-0651549;F10418;Q27893568

Chemical Property of 2,3-Dichloro-5-(trichloromethyl)pyridine

Chemical Property:

• Vapor Pressure: 0.00306mmHg at 25°C
• Refractive Index: n20/D 1.5900(lit.)
• Boiling Point: 293.229 °C at 760 mmHg
• PKA: -3.03±0.10(Predicted)
• Flash Point: 158.979 °C
• PSA: 12.89000
• Density: 1.681 g/cm³
• LogP: 4.21510
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 264.860037
• Heavy Atom Count: 12
• Complexity: 157

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dichloro-5-(trichloromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1Cl)Cl)C(Cl)(Cl)Cl

Technology Process of 2,3-Dichloro-5-(trichloromethyl)pyridine

There total 20 articles about 2,3-Dichloro-5-(trichloromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.82%

2,3-dichloro-5-(methyl)pyridine (59782-90-0) → 2,3-dichloro-5-(trichloromethyl)pyridine (69045-83-6)

Guidance literature:

2,3-dichloro-5-(methyl)pyridine; With chlorine; molybdenum; at 110 - 120 ℃; for 14h;

at 100 - 110 ℃; for 0.5h; under 200 Torr; Temperature; Pressure; Reagent/catalyst;

Reference yield: 90.0%

2-chloro-5-(Trichloromethyl)-pyridine (69045-78-9) → 2,3-dichloro-5-(trichloromethyl)pyridine (69045-83-6)

Guidance literature:

With chlorine; at 150 - 160 ℃; for 6h;

Reference yield: 79.0%

2-chloro-5-(chloromethyl)pyridine (70258-18-3) → 2,3-dichloro-5-(trichloromethyl)pyridine (69045-83-6)

Guidance literature:

With manganese(IV) oxide; iron(III) chloride; chlorine; at 120 ℃; for 45h; under 760.051 Torr; Reagent/catalyst; Temperature;

upstream raw materials:

2-bromo-3-chloro-5-methyl-pyridine

3-Methylpyridine

P,P-dichlorophenylphosphine oxide

5-chloro-6-hydroxy-3-pyridinecarboxylic acid

Downstream raw materials:

5-chloromethyl-2,3-dichloropyridine

2,3-dichloro-5-trifluoromethylpyridine

3,5-dichloro-4-[(3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy]aniline

chlorfluazuron

Refernces

• 1、 -. "Method for efficiently synthesizing pyridine chlorides". Paragraph 0025; 0028-0030; 0033-0035; 0038-0040; 0043-0045. . Retrieved 2020/06/09.
• 2、 -. "A 2 - chloro -5 - nitrapyrin preparation method". Paragraph 0031-0032. . Retrieved 2019/03/15.