Bicyclo[4.2.0]octan-7-one

Base Information

• Chemical Name: Bicyclo[4.2.0]octan-7-one
• CAS No.: 54211-18-6
• Molecular Formula: C₈H₁₂O
• Molecular Weight: 124.183
• Mol file: 54211-18-6.mol

Synonyms:Bicyclo[4,2,0]octan-7-one;rac-bicyclo[4.2.0]octan-7-one;bicyclo [4.2.0]octan-7-one;BICYCLO[4.2.0]OCTAN-7-ONE;

Chemical Property of Bicyclo[4.2.0]octan-7-one

Chemical Property:

• PSA: 17.07000
• LogP: 1.76560

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Bicyclo[4.2.0]octan-7-one

There total 10 articles about Bicyclo[4.2.0]octan-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

bicyclo[4.2.0]-oct-2-en-7-one (31996-68-6) → bicyclo[4.2.0]octan-7-one (54211-18-6,74897-70-4,109660-29-9,130853-15-5,27655-70-5)

Guidance literature:

With hydrogen; palladium; In ethyl acetate; at 24 ℃; for 24h;

DOI:10.1021/jo00304a020

Reference yield: 34.0%

N,N-dimethyl acetamide (127-19-5,116057-81-9) + cyclohexene (110-83-8) → bicyclo[4.2.0]octan-7-one (54211-18-6,74897-70-4,109660-29-9,130853-15-5,27655-70-5)

Guidance literature:

N,N-dimethyl acetamide; With trifluoromethylsulfonic anhydride; In 1,2-dichloro-ethane; at -30 ℃; for 0.5h; Inert atmosphere;

cyclohexene; With 2,4,6-trimethyl-pyridine; In 1,2-dichloro-ethane; Inert atmosphere; Reflux;

DOI:10.1021/acs.joc.9b01290

Reference yield:

8,8-dichlorobicyclo[4.2.0]octan-7-one (32166-29-3,109632-81-7,13866-27-8) → bicyclo[4.2.0]octan-7-one (54211-18-6,74897-70-4,109660-29-9,130853-15-5,27655-70-5)

Guidance literature:

With acetic acid; zinc;

DOI:10.1039/C39740000383

upstream raw materials:

8,8-dichlorobicyclo[4.2.0]octan-7-one

2,2,2-trifluoroethanol

bicyclo<4.2.0>oct-1(8)-en-8-yl nonaflate

bicyclo[4.1.0]heptane

Downstream raw materials:

tosylhydrazone of bicyclo<4.2.0>octan-7-one

(3aR,7aR)-hexahydrobenzofuran-2(3H)-one

(3aS,7aS)-hexahydrobenzofuran-2(3H)-one

(1S,6R)-8-oxabicyclo[4.3.0]nonan-7-one