2-Hydroxyheptanoic acid methyl ester

Base Information

• Chemical Name: 2-Hydroxyheptanoic acid methyl ester
• CAS No.: 54340-91-9
• Molecular Formula: C8H16O3
• Molecular Weight: 160.21100
• Hs Code.: 2918199090
• Mol file: 54340-91-9.mol

Synonyms:2-Hydroxy-oenanthsaeure-methylester;methyl 2-hydroxy heptanoate;2-Hydroxy-heptansaeure-methylester;Heptanoic acid,2-hydroxy-,methyl ester,(S);methyl rac-2-hydroxyheptanoate;2-hydroxy-enanthic acid methyl ester;Heptanoic acid,2-hydroxy-,methyl ester;

Chemical Property of 2-Hydroxyheptanoic acid methyl ester

Chemical Property:

• PSA: 46.53000
• LogP: 1.10060

Purity/Quality:

99% ^*data from raw suppliers

methyl2-hydroxyheptanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Hydroxyheptanoic acid methyl ester

There total 12 articles about 2-Hydroxyheptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

E-methoxy-1 trimethylsiloxy-1 heptene-1 (78935-59-8) → methyl rac-2-hydroxyheptanoate (54340-91-9)

Guidance literature:

With fluorine; In chloroform; water; acetonitrile; at 0 - 20 ℃; for 0.0833333h;

DOI:10.1016/S0040-4020(98)01173-9

Reference yield: 72.0%

methanol (67-56-1) + 1,1,1-Tris-ethylsulfanyl-heptan-2-ol (82722-11-0) → methyl rac-2-hydroxyheptanoate (54340-91-9)

Guidance literature:

With tetrafluoroboric acid; mercury(II) oxide; In tetrahydrofuran; for 1h; Ambient temperature;

Reference yield: 57.0%

1,1,1-tris(methylthio)-2-heptanol (81114-75-2) → methyl rac-2-hydroxyheptanoate (54340-91-9)

Guidance literature:

With mercury dichloride; mercury(II) oxide; In methanol; for 1h; Heating;

DOI:10.1246/bcsj.62.2013

upstream raw materials:

methyl heptanoate

diazomethane

2-hydroxyheptanoic acid

methanol

Downstream raw materials:

(E)-methyl hept-3-enoate

α-Acetoxy-heptansaeure-methylester

Refernces

• 1、 Dayan, Sharon,Bareket, Yifat,Rozen, Shlomo. "An efficient α-hydroxylation of carbonyls using the HOF·CH3CN complex". . p. 3657 - 3664. Retrieved 2007/10/03.
• 2、 Mohan, H Rama,Rao, A S. "A convenient route for the homologation of saturated esters to α,β-unsaturated esters". . p. 698 - 700. Retrieved 2007/10/02.