7-Bromo-2-(3-fluoro-4-methoxyphenyl)-5-methoxy-1,3-benzoxazole

Base Information

Chemical Name:7-Bromo-2-(3-fluoro-4-methoxyphenyl)-5-methoxy-1,3-benzoxazole
CAS No.:544704-75-8
Molecular Formula:C15H11BrFNO3
Molecular Weight:352.16
Hs Code.:
DSSTox Substance ID:DTXSID501195112
Mol file:544704-75-8.mol

Synonyms:544704-75-8;7-bromo-2-(3-fluoro-4-methoxyphenyl)-5-methoxy-1,3-benzoxazole;7-Bromo-2-(3-fluoro-4-methoxyphenyl)-5-methoxybenzo[d]oxazole;SCHEMBL4463663;PZQOAJQYQBQTMZ-UHFFFAOYSA-N;DTXSID501195112;AMY37391;CS-D0253;AKOS025394017;D77325;7Y-0058;7-Bromo-2-(3-fluoro-4-methoxyphenyl)-5-methoxybenzoxazole;Benzoxazole, 7-bromo-2-(3-fluoro-4-methoxyphenyl)-5-methoxy-

Suppliers and Price of 7-Bromo-2-(3-fluoro-4-methoxyphenyl)-5-methoxy-1,3-benzoxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 7-Bromo-2-(3-fluoro-4-methoxyphenyl)-5-methoxy-1,3-benzoxazole

Chemical Property:

PSA：44.49000
LogP:4.41360
XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:350.99063
Heavy Atom Count:21
Complexity:362

Purity/Quality:: NLT 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)C2=NC3=C(O2)C(=CC(=C3)OC)Br)F

Technology Process of 7-Bromo-2-(3-fluoro-4-methoxyphenyl)-5-methoxy-1,3-benzoxazole

There total 6 articles about 7-Bromo-2-(3-fluoro-4-methoxyphenyl)-5-methoxy-1,3-benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 544704-74-7
2-bromo-6-[(3-fluoro-4-methoxybenzoyl)amino]-4-methoxyphenyl-3-fluoro-4-methoxybenzoate

: 544704-75-8
7-bromo-2-(3-fluoro-4-methoxyphenyl)-5-methoxy-1,3-benzoxazole

Guidance literature:: With toluene-4-sulfonic acid; In para-xylene; for 3h; Heating / reflux; Dean-Stark Trap;

Reference yield:

: 1568-70-3
4-methoxy-2-nitrophenol

: 544704-75-8
7-bromo-2-(3-fluoro-4-methoxyphenyl)-5-methoxy-1,3-benzoxazole

Guidance literature:: Multi-step reaction with 4 steps

1: bromine; NaOAc; AcOH / 2.5 h / 20 - 70 °C

2: 96 percent / H₂ / tetrahydrofuran / 2.5 h / 1292.87 Torr

3: 46.5 g / pyridine / CH₂Cl₂ / 0 °C

4: 81 percent / p-toluenesulfonic acid monohydrate; p-xylene / 3 h / Heating

With pyridine; para-xylene; hydrogen; bromine; sodium acetate; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm049719y

Reference yield:

: 403-20-3
3-fluoro-p-anisic acid

: 544704-75-8
7-bromo-2-(3-fluoro-4-methoxyphenyl)-5-methoxy-1,3-benzoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride; DMF / 1 h / Heating

2: 46.5 g / pyridine / CH₂Cl₂ / 0 °C

3: 81 percent / p-toluenesulfonic acid monohydrate; p-xylene / 3 h / Heating

With pyridine; thionyl chloride; para-xylene; toluene-4-sulfonic acid; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm049719y