4-(4,5-DIHYDRO-1,3-OXAZOL-2-YL)ANILINE

Base Information

• Chemical Name: 4-(4,5-DIHYDRO-1,3-OXAZOL-2-YL)ANILINE
• CAS No.: 54472-46-7
• Molecular Formula: C9H10N2O
• Molecular Weight: 162.191
• Hs Code.: 2934999090
• Mol file: 54472-46-7.mol

Synonyms:4-(4,5-dihydro-2-oxazolyl)benzamine;2-(p-Aminophenyl)oxazoline;4-(4,5-Dihydrooxazol-2-yl)phenylamine;4-(4,5-Dihydrooxazol-2-yl)aniline;4-(1,3-oxazolin-2-yl)phenylamine;4-(4,5-Dihydro-oxazol-2-yl)-anilin;

Chemical Property of 4-(4,5-DIHYDRO-1,3-OXAZOL-2-YL)ANILINE

Chemical Property:

• PSA: 47.61000
• LogP: 1.06240

Purity/Quality:

98%Min ^*data from raw suppliers

4-(4,5-DIHYDRO-1,3-OXAZOL-2-YL)ANILINE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4,5-DIHYDRO-1,3-OXAZOL-2-YL)ANILINE

There total 5 articles about 4-(4,5-DIHYDRO-1,3-OXAZOL-2-YL)ANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

ethanolamine (141-43-5) + 4-Aminobenzonitrile (873-74-5) → 4-(4,5-Dihydrooxazol-2-yl)aniline (54472-46-7)

Guidance literature:

With [RuCl(CO)(PPh₃)₂(2-((2,6-dimethylphenylimino)methyl)quinolin-8-ol)]; In neat (no solvent); at 90 ℃; for 5h;

DOI:10.1016/j.jorganchem.2015.06.005

Reference yield:

4-nitro-benzoic acid (62-23-7) → 4-(4,5-Dihydrooxazol-2-yl)aniline (54472-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc(II) chloride

2: palladium 10% on activated carbon; ammonium formate / ethanol / Reflux

With palladium 10% on activated carbon; ammonium formate; zinc(II) chloride; In ethanol;

DOI:10.1016/j.bmcl.2011.05.131

Reference yield:

4-nitrobenzaldehdye (555-16-8) → 4-(4,5-Dihydrooxazol-2-yl)aniline (54472-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tert-butyl alcohol / 4 h / 70 °C

1.2: 70 °C

2.1: ammonium chloride; iron / water; ethanol / 2 h / Reflux

With iron; ammonium chloride; In ethanol; water; tert-butyl alcohol;

upstream raw materials:

N-(2-Hydroxyethyl)-4-aminobenzamide

4-nitro-benzoic acid

ethanolamine

4-Aminobenzonitrile