2,4-Pentadienamide, 2-cyano-5-(dimethylamino)-5-phenyl-

Base Information

• Chemical Name: 2,4-Pentadienamide, 2-cyano-5-(dimethylamino)-5-phenyl-
• CAS No.: 54818-68-7
• Molecular Formula: C14H15N3O
• Molecular Weight: 241.28800
• Mol file: 54818-68-7.mol

Synonyms:2-cyano-5-(dimethylamine)-5-phenylpenta-2,4-dienamide;2-cyano-5-dimethylamino-5-phenylpenta-2,4-dienoic acid amide;2,4-Pentadienamide,2-cyano-5-(dimethylamino)-5-phenyl;2-Cyano-5-dimethylamino-5-phenyl-penta-2,4-diensaeureamid;

Chemical Property of 2,4-Pentadienamide, 2-cyano-5-(dimethylamino)-5-phenyl-

Chemical Property:

• PSA: 71.11000
• LogP: 2.67408

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Pentadienamide, 2-cyano-5-(dimethylamino)-5-phenyl-

There total 4 articles about 2,4-Pentadienamide, 2-cyano-5-(dimethylamino)-5-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-phenyl-3-dimethylaminoprop-2-enone (1201-93-0) + malononitrile (109-77-3) → 2-cyano-5-dimethylamino-5-phenylpenta-2,4-dienoic acid amide (54818-68-7)

Guidance literature:

With chitosan-grafted-poly(4-vinylpyridine) beads; In ethanol; for 3h; Reflux;

DOI:10.3390/molecules18055288

Reference yield: 84.0%

3,3-Bis(dimethylamino)-1-phenyl-prop-1-in (19176-74-0) + cyanoacetic acid amide (107-91-5) → 2-cyano-5-dimethylamino-5-phenylpenta-2,4-dienoic acid amide (54818-68-7)

Guidance literature:

In tetrahydrofuran; Heating;

DOI:10.1002/prac.19973390130

Reference yield:

acetophenone (98-86-2) → 2-cyano-5-dimethylamino-5-phenylpenta-2,4-dienoic acid amide (54818-68-7)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) POCl₃, (ii) /BRN= 605842/, (iii) aq. NaClO₄, EtOH

2: NaOEt / ethanol

With sodium ethanolate; In ethanol;

upstream raw materials:

3-chloro-3-phenyl-1-prop-2-en-1-yliden-dimethyliminium perchlorate

cyanoacetic acid amide

3,3-Bis(dimethylamino)-1-phenyl-prop-1-in

acetophenone

Downstream raw materials:

1,2-dihydro-2-oxo-6-phenylpyridine-3-carbonitrile

2-oxo-6-phenyl-1,2-dihydropyridine-3-carboxylic acid