Technology Process of quinuclidine-4-carbaldehyde
There total 6 articles about quinuclidine-4-carbaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-cyanoquinuclidine;
With
diisobutylaluminium hydride;
In
hexanes; dichloromethane;
at -78 ℃;
With
water; rochelle salt;
In
hexanes; dichloromethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / acetone / 18 h / 25 °C
2: n-butyllithium; diisopropylamine; lithium diisopropyl amide / tetrahydrofuran; hexane / 21 h / -78 - 25 °C
3: lithium aluminium tetrahydride / diethyl ether / 5.33 h / 26 - 60 °C
4: silver(I) carbonate dispersed on celite? / toluene / 19 h / 110 °C / Dean-Stark
With
lithium aluminium tetrahydride; n-butyllithium; potassium carbonate; diisopropylamine; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; hexane; acetone; toluene;
DOI:10.1002/anie.201610884