4-Piperidinecarboxylic acid, 1-(2-chloroethyl)-, ethyl ester

Base Information

Chemical Name:4-Piperidinecarboxylic acid, 1-(2-chloroethyl)-, ethyl ester
CAS No.:869112-14-1
Molecular Formula:C10H18ClNO2
Molecular Weight:219.711
Hs Code.:
Mol file:869112-14-1.mol

Synonyms:4-Piperidinecarboxylic acid,1-(2-chloroethyl)-,ethyl ester;ethyl 1-(2-chloroethyl)-4-piperidinecarboxylate;

Suppliers and Price of 4-Piperidinecarboxylic acid, 1-(2-chloroethyl)-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(2-Chloroethyl)-4-piperidinecarboxylicAcidEthylEster
2.5g
$ 255.00

Crysdot
Ethyl1-(2-chloroethyl)piperidine-4-carboxylate 95+%
10g
$ 591.00

Crysdot
Ethyl1-(2-chloroethyl)piperidine-4-carboxylate 95+%
5g
$ 394.00

ChemScene
Ethyl1-(2-chloroethyl)piperidine-4-carboxylate
1g
$ 125.00

Total 12 raw suppliers

Chemical Property of 4-Piperidinecarboxylic acid, 1-(2-chloroethyl)-, ethyl ester

Chemical Property:

Boiling Point:279.7±35.0 °C(Predicted)
PKA:7.50±0.10(Predicted)
PSA：29.54000
Density:1.095±0.06 g/cm3(Predicted)
LogP:1.43820

Purity/Quality:

97% ^*data from raw suppliers

1-(2-Chloroethyl)-4-piperidinecarboxylicAcidEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 1-(2-Chloroethyl)-4-piperidinecarboxylic Acid Ethyl Ester is an intermediate in the synthesis of Umeclidinium Bromide, which is considered as a potentially long-acting antimuscarinic agent.

Technology Process of 4-Piperidinecarboxylic acid, 1-(2-chloroethyl)-, ethyl ester

There total 8 articles about 4-Piperidinecarboxylic acid, 1-(2-chloroethyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 107-20-0
2-chloroethanal

: 1126-09-6
4-carbethoxypiperidine

: 869112-14-1
1-(2-chloroethyl)-4-piperidinecarboxylic acid ethyl ester

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; water; at 0 - 20 ℃; for 2h; Solvent; Reagent/catalyst;

Reference yield: 80.0%

: 1126-09-6
4-carbethoxypiperidine

: 540-51-2
2-bromoethanol

: 869112-14-1
1-(2-chloroethyl)-4-piperidinecarboxylic acid ethyl ester

Guidance literature:: 4-carbethoxypiperidine; 2-bromoethanol; With potassium carbonate; In toluene; at 110 ℃; for 2.66667h; Reflux;

With thionyl chloride; In ethyl acetate; toluene; at 20 - 50 ℃; for 1.66667h;

Reference yield: 76.0%

: 75-21-8,99932-75-9
oxirane

: 1126-09-6
4-carbethoxypiperidine

: 869112-14-1
1-(2-chloroethyl)-4-piperidinecarboxylic acid ethyl ester

Guidance literature:: oxirane; 4-carbethoxypiperidine; In dichloromethane; at 40 - 45 ℃; Industrial scale;

With thionyl chloride; triethylamine; In dichloromethane; Industrial scale;