3'-Chloro-4'-hydroxybenzophenone

Base Information

• Chemical Name: 3'-Chloro-4'-hydroxybenzophenone
• CAS No.: 55191-20-3
• Molecular Formula: C13H9ClO2
• Molecular Weight: 232.666
• Hs Code.: 2914700090
• Mol file: 55191-20-3.mol

Synonyms:3-Chlor-4-hydroxy-benzophenon;4-hydroxy-3-chlorobenzophone;3'-Chloro-4'-hydroxybenzophenone;(3-chloro-4-hydroxyphenyl)phenyl-methanone;3-Chlor-4-hydroybenzophenon;Methanone,(3-chloro-4-hydroxyphenyl)phenyl;Methanone, (3-chloro-4-hydroxyphenyl)phenyl-;4-benzoyl-2-chlorophenol;

Chemical Property of 3'-Chloro-4'-hydroxybenzophenone

Chemical Property:

• Melting Point: 170-173°C
• PSA: 37.30000
• LogP: 3.27660
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

(3-CHLORO-4-HYDROXYPHENYL)(PHENYL)METHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Fenofibric Acid intermediate.

Technology Process of 3'-Chloro-4'-hydroxybenzophenone

There total 13 articles about 3'-Chloro-4'-hydroxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

→ (3-chloro-4-hydroxyphenyl)(phenyl)methanone (55191-20-3)

Guidance literature:

Reference yield: 90.0%

2-Chloro-1,4-benzoquinone (695-99-8) + phenylacetylene (536-74-3) → (3-chloro-4-hydroxyphenyl)(phenyl)methanone (55191-20-3)

Guidance literature:

With dipotassium peroxodisulfate; trifluoroacetic acid; In water; acetonitrile; at 25 ℃; for 6h; Irradiation;

DOI:10.1021/acs.joc.9b00855

Reference yield: 70.0%

3,4-dichlorobenzophenone (6284-79-3) → (3-chloro-4-hydroxyphenyl)(phenyl)methanone (55191-20-3) + (4-hydroxy-3-nitrophenyl)(phenyl)methanone (5464-98-2)

Guidance literature:

With sodium nitrite; In dimethyl sulfoxide; at 170 ℃; for 10h;

DOI:10.1055/s-1992-26192

upstream raw materials:

(3-chloro-4-methoxyphenyl)(phenyl)methanone

2-monochlorophenol

benzoyl chloride

2-Chloroanisole

Downstream raw materials:

[3-chloro-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-phenyl-methanone

1-[3-Chlor-4-(2-dimethylamino-1-methyl-aethoxy)-phenyl]-2-(4-chlor-phenyl)-1-phenyl-aethanol

[3-chloro-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-phenyl-methanol

3-Chlor-4-<2-dimethylamino-1-methyl-aethoxy>-benzophenon

Refernces

• 1、 -. "LTA4 Hydrolase inhibitors". Page 56. . Retrieved 2010/01/31.
• 2、 Harjani, Jitendra R.,Nara, Susheel J.,Salunkhe, Manikrao M.. "Fries rearrangement in ionic melts". . p. 1979 - 1981. Retrieved 2007/10/03.