D-TYROSINE ETHYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: D-TYROSINE ETHYL ESTER HYDROCHLORIDE
• CAS No.: 23234-43-7
• Molecular Formula: C11H15NO3^.HCl
• Molecular Weight: 245.706
• Hs Code.: 2922509090
• Mol file: 23234-43-7.mol

Synonyms:D-Tyrosine,ethyl ester, hydrochloride (9CI);Tyrosine, ethyl ester, hydrochloride, D-(8CI);Ethyl D-tyrosinate hydrochloride;

Chemical Property of D-TYROSINE ETHYL ESTER HYDROCHLORIDE

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 4.14E-06mmHg at 25°C
• Boiling Point: 373.5 °C at 760 mmHg
• Flash Point: 179.7 °C
• PSA: 72.55000
• LogP: 2.32740
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

D-Tyrosine ethyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-TYROSINE ETHYL ESTER HYDROCHLORIDE

There total 12 articles about D-TYROSINE ETHYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-methyl-2-phenylpropyloxy)nitrobenzene (62517-29-7) → D-tyrosine ethyl ester hydrochloride (23234-43-7)

Guidance literature:

Multi-step reaction with 8 steps

1: H₂ / 10percent Pd/C / benzene; ethanol / 760 Torr / Ambient temperature

2: 1.) 33percent NaNO₂/H₂O, conc. HCl, ethyl acrylate, 2.) Cu₂O / 1.) acetone, ice cooling, 2.) 40 deg C, 2 h

3: 29.1 g / 25percent NaOH/H₂O / methanol

5: 360 mg / 20percent HCl / 4 h / Ambient temperature

6: 220 mg / BBr₃ / CH₂Cl₂ / 0.33 h / Ambient temperature

7: 200 mg / NaN₃ / dimethylsulfoxide; H₂O / 3 h / 90 °C

8: 1.) H₂, 2.) HCl/Et₂O / 1.) 10percent Pd/C / 1.) ethanol, 1 atm, r.t.

With copper(I) oxide; hydrogenchloride; sodium hydroxide; sodium azide; diethyl ether; water; hydrogen; boron tribromide; ethyl acrylate; sodium nitrite; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; benzene;

Reference yield:

4-(2-methyl-2-phenylpropyloxy)aniline (62517-30-0) → D-tyrosine ethyl ester hydrochloride (23234-43-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) 33percent NaNO₂/H₂O, conc. HCl, ethyl acrylate, 2.) Cu₂O / 1.) acetone, ice cooling, 2.) 40 deg C, 2 h

2: 29.1 g / 25percent NaOH/H₂O / methanol

4: 360 mg / 20percent HCl / 4 h / Ambient temperature

5: 220 mg / BBr₃ / CH₂Cl₂ / 0.33 h / Ambient temperature

6: 200 mg / NaN₃ / dimethylsulfoxide; H₂O / 3 h / 90 °C

7: 1.) H₂, 2.) HCl/Et₂O / 1.) 10percent Pd/C / 1.) ethanol, 1 atm, r.t.

With copper(I) oxide; hydrogenchloride; sodium hydroxide; sodium azide; diethyl ether; water; hydrogen; boron tribromide; ethyl acrylate; sodium nitrite; palladium on activated charcoal; In methanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

2-chloro-3-<4-(2-methyl-2-phenylpropyloxy)phenyl>propionic acid (62516-93-2,74401-61-9,74401-70-0) → D-tyrosine ethyl ester hydrochloride (23234-43-7)

Guidance literature:

Multi-step reaction with 5 steps

2: 360 mg / 20percent HCl / 4 h / Ambient temperature

3: 220 mg / BBr₃ / CH₂Cl₂ / 0.33 h / Ambient temperature

4: 200 mg / NaN₃ / dimethylsulfoxide; H₂O / 3 h / 90 °C

5: 1.) H₂, 2.) HCl/Et₂O / 1.) 10percent Pd/C / 1.) ethanol, 1 atm, r.t.

With hydrogenchloride; sodium azide; diethyl ether; hydrogen; boron tribromide; palladium on activated charcoal; In dichloromethane; water; dimethyl sulfoxide;

upstream raw materials:

ethyl 2-azido-3-(4-hydroxyphenyl)propionate

4-(2-methyl-2-phenylpropyloxy)nitrobenzene

4-(2-methyl-2-phenylpropyloxy)aniline

2-chloro-3-<4-(2-methyl-2-phenylpropyloxy)phenyl>propionic acid

Downstream raw materials:

(R)-ethyl 2-(2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)-3-(4-hydroxyphenyl)propanoate

D-prolyl-D-tyrosine amide trifluoroacetate