62517-29-7

Upstream product

• 2173-69-5 2-methyl-2-phenyl-propan-1-ol 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 62517-30-0 4-(2-methyl-2-phenylpropyloxy)aniline 
• 85021-62-1 4-amino-2-imino-5-<4-(2-methyl-2-phenylpropoxy)benzyl>-Δ⁴-thiazoline monohydrate 
• 85021-64-3 3-methyl-5-<4-(2-methyl-2-phenylpropoxy)benzyl>thiazolidin-2,4-dione 
• 85021-63-2 2-bromo-3-<4-(2-methyl-2-phenylpropoxy)phenyl>propionitrile 
• 74772-68-2 5-[4-(2-methyl-2-phenylpropyloxy)-benzyl]thiazolidine-2,4-dione 
• 74401-62-0 ethyl 2-chloro-3-(4-hydroxyphenyl)propionate 
• 74401-65-3 ethyl 2-azido-3-(4-hydroxyphenyl)propionate 

Relevant academic research and scientific papers

Studies on antihyperlipidemic agents. III. Synthesis and biological activities of 2-chloro-3-arylpropionic acids containing a quarternary carbon atom

A series of 2-chloro-3-(4-alkoxyphenyl)propionic acids containing a quarternary carbon atom in the alkoxy moiety was prepared and the hypolipidemic and hypoglycemic activities were evaluated. Of the 18 compounds synthesized, ethyl 2-chloro-3-[4-(2-methyl-2-phenylpropyloxy)phenyl]propionate was the best with respect to biological activity and toxicity. Its functional derivatives and optically resolved enantiomers were also prepared. Structure-activity relationships are discussed briefly.

α-Chlorocarboxylic acids

α-CHLOROCARBOXYLIC ACIDS OF THE FORMULA STR1 wherein Y stands for a lower alkyl group having 1 to 6 carbon atoms or a phenyl group, a benzoyl group or a phenylalkyl group having 7 to 11 carbon atoms, which may have a lower alkyl group having 1 to 3 carbon atoms, a lower alkoxy group having 1 to 3 carbon atoms or a halogen on the phenyl rings as a substituent; R1 stands for a lower alkylene group having 1 to 4 carbon atoms or a valency bond; L stands for a lower alkyl group having 1 to 3 carbon atoms; and Z stands for a carboxyl group or a group convertible to carboxyl group, are useful as, for example, remedies for hyperlipemia, diabetes and so on of mammals including human beings.