(CIS-1-AMINO-INDAN-2-YL)-METHANOL

Base Information

• Chemical Name: (CIS-1-AMINO-INDAN-2-YL)-METHANOL
• CAS No.: 55270-04-7
• Molecular Formula: C10H13NO
• Molecular Weight: 163.21600
• Hs Code.: 2922190090
• Mol file: 55270-04-7.mol

Synonyms:cis-1-Amino-2-indan-methanol;

Chemical Property of (CIS-1-AMINO-INDAN-2-YL)-METHANOL

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 81 - 83 °C
• Boiling Point: 301.88oC at 760 mmHg
• Flash Point: 136.372oC
• PSA: 46.25000
• Density: 1.128g/cm3
• LogP: 1.55130

Purity/Quality:

98%min ^*data from raw suppliers

(cis-1-Amino-indan-2-yl)-methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (CIS-1-AMINO-INDAN-2-YL)-METHANOL

There total 4 articles about (CIS-1-AMINO-INDAN-2-YL)-METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(1R,2R)-1-amino-2,3-dihydro-1H-indene-2-carboxylic acid (135053-20-2,887127-22-2) → [(1R,2R)-1-amino-2,3-dihydro-1H-inden-2-yl] methanol (55269-97-1,55270-04-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Inert atmosphere; Reflux;

DOI:10.1021/ml300407y

Reference yield:

1-indene (95-13-6) → [(1R,2R)-1-amino-2,3-dihydro-1H-inden-2-yl] methanol (55269-97-1,55270-04-7)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether / 3 h / 20 °C / Inert atmosphere

2: water / di-isopropyl ether / 60 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction

3: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; water; In tetrahydrofuran; diethyl ether; di-isopropyl ether; 1: |Diels-Alder Cycloaddition;

DOI:10.1021/ml300407y

Reference yield:

(±)-3,4-benzo-cis-6-azabicyclo[3.2.0]heptane-7-one → [(1R,2R)-1-amino-2,3-dihydro-1H-inden-2-yl] methanol (55269-97-1,55270-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1: lipase B; water / di-isopropyl ether / 60 °C / Enzymatic reaction

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Reflux

With lithium aluminium tetrahydride; lipase B; water; In tetrahydrofuran; di-isopropyl ether;

upstream raw materials:

1-indene

(1R,2R)-1-amino-2,3-dihydro-1H-indene-2-carboxylic acid

Downstream raw materials:

(+)-N¹-(4-chloro-3-fluorophenyl)-N²-(trans-2-(guanidinomethyl)indan-1-yl)oxalamide formate salt

N¹-((1R,2R)-2-(aminomethyl)-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl)-oxalamide

N¹-((1R,2R)-2-(azidomethyl)-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl) oxalamide

[(1R,2S)-1-{(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl}methyl] methanesulfonate

Refernces

• 1、 -. "CD4-MIMETIC INHIBITORS OF HIV-1 ENTRY AND METHODS OF USE THEREOF". . . Retrieved 2013/07/05.