1-(4-Iodophenyl)piperidine

Base Information

• Chemical Name: 1-(4-Iodophenyl)piperidine
• CAS No.: 55376-34-6
• Molecular Formula: C11H14IN
• Molecular Weight: 287.143
• DSSTox Substance ID: DTXSID00527308
• Nikkaji Number: J1.928.500F
• Wikidata: Q82396487
• Mol file: 55376-34-6.mol

Synonyms:1-(4-iodophenyl)piperidine;55376-34-6;SCHEMBL133561;DTXSID00527308;PIVBPXLBAWYSSK-UHFFFAOYSA-N;MFCD22418495;AKOS020188391;AS-44207

Chemical Property of 1-(4-Iodophenyl)piperidine

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 287.01710
• Heavy Atom Count: 13
• Complexity: 146

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCN(CC1)C2=CC=C(C=C2)I

Technology Process of 1-(4-Iodophenyl)piperidine

There total 12 articles about 1-(4-Iodophenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

piperidine (110-89-4) + 4-iodophenyl trifluoromethanesulfonate (109586-39-2) → 1-(4-iodophenyl)piperidine (55376-34-6)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 200 - 204 ℃; for 0.75h; microwave irradiation;

DOI:10.1021/ol049963j

Reference yield: 81.0%

piperidine (110-89-4) + 1-Chloro-4-iodobenzene (637-87-6) → 1-(4-iodophenyl)piperidine (55376-34-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 9h;

DOI:10.1055/s-0029-1216890

Reference yield: 78.0%

trifluoromethanesulfonic acid 1,5-pentanediyl ester (63256-91-7) + p-aminoiodobenzene (540-37-4) → 1-(4-iodophenyl)piperidine (55376-34-6)

Guidance literature:

With triethylamine; In ethanol; at 90 ℃; for 24h; Sealed tube;

DOI:10.1016/j.molliq.2015.01.043

upstream raw materials:

1,5-dibromo-pentane

p-aminoiodobenzene

piperidine

para-diiodobenzene

Downstream raw materials:

1-(2-oxopyrrolidin-1-yl)-4-iodobenzene