Pyridine, 2-(2-furanyl)-

Base Information

• Chemical Name: Pyridine, 2-(2-furanyl)-
• CAS No.: 55484-03-2
• Molecular Formula: C9H7NO
• Molecular Weight: 145.161
• Mol file: 55484-03-2.mol

Synonyms:2-furan-2-ylpyridine;

Chemical Property of Pyridine, 2-(2-furanyl)-

Chemical Property:

• PSA: 26.03000
• LogP: 2.34160

Purity/Quality:

99% ^*data from raw suppliers

2-(Furan-2-yl)pyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyridine, 2-(2-furanyl)-

There total 27 articles about Pyridine, 2-(2-furanyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

furan (110-00-9) + 2-chloropyridine (109-09-1) → 2-(2'-furyl)pyridine (55484-03-2)

Guidance literature:

furan; With n-butyllithium;

With zinc(II) chloride;

2-chloropyridine; nickel phosphine amido pincer complex; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 70 ℃; for 12h; Further stages.;

DOI:10.1021/ol701927g

Reference yield: 94.0%

trimethylpyridin-2-ylammonium iodide (33675-27-3) + 2-furylzinc chloride (81745-86-0) → 2-(2'-furyl)pyridine (55484-03-2)

Guidance literature:

With C₃₂H₂₆ClN₂NiP; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 85 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jo300209d

Reference yield: 93.0%

2-chloropyridine (109-09-1) + fur-2-ylboronic acid (13331-23-2) → 2-(2'-furyl)pyridine (55484-03-2)

Guidance literature:

With C₈₄H₆₄Cl₃N₃Pd; potassium carbonate; In ethanol; at 80 ℃; for 2h;

DOI:10.1002/cctc.201701076

upstream raw materials:

1,2-dichloroethyl acetate

ethyl 2-pyridylcarbonylacetate

furan

2-bromo-pyridine

Downstream raw materials:

C₁₇H₁₃NO₂

2-(pyridin-2-yl)-3-furancarboxylic acid methyl ester

(Methyl-3 furyl-2)-2 pyridine

(Phenylhydroxymethyl-3 furyl-2)-2 pyridine

Refernces

• 1、 Ouyang, Jia-Sheng,Li, Yan-Fang,Huang, Fei-Dong,Lu, Dong-Dong,Liu, Feng-Shou. "The Highly Efficient Suzuki–Miyaura Cross-Coupling of (Hetero)aryl Chlorides and (Hetero)arylboronic Acids Catalyzed by “Bulky-yet-Flexible” Palladium–PEPPSI Complexes in Air". . p. 371 - 375. Retrieved 2017/12/15.
• 2、 Savanur, Hemantkumar M.,Kalkhambkar, Rajesh G.,Laali, Kenneth K.. "Piperidine-appended imidazolium ionic liquid as task-specific basic-IL for Suzuki and Heck reactions and for tandem Wittig-Suzuki, Wittig-Heck, Horner-Emmons-Suzuki, and Horner-Emmons-Heck protocols". . p. 150 - 161. Retrieved 2017/06/30.